Research Article
Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors
Table 1
Structures and analytical data of tripeptides synthesized.
| | Peptide | Structure | HPLC | ESI-MS |
Yield | | tR | found | calc |
| | S1 | GMD | 10.50 | 322.08 | 321.10 | 75% | | S2 | ERA | 9.99 | 375.3 | 374.19 | 80 % | | S3 | GHE | 8.08 | 342.14 | 341.13 | 67% | | S4 | GER | 10.00 | 361.17 | 360.18 | 80% | | S5 | DRC | 9.89 | 393.20 | 392.15 | 62% | | S6 | ARA | 10.46 | 317.24 | 316.19 | 68% | | S7 | PER | 8.87 | 401.40 | 400.21 | 81% | | S8 | KHI | 10.98 | 397.11 | 396.25 | 80% | | S9 | AER | 11.00 | 375.32 | 374.19 | 75% | | S10 | AGR | 9.03 | 303.34 | 302.17 | 79% | | E1 | SRH | 8.95 | 399.30 | 398.20 | 68% | | E2 | SWE | 8.04 | 421.0 | 420.16 | 69% | | E3 | IRT | 8.03 | 389.3 | 388.24 | 76% | | E4 | SMD | 8.00 | 342.16 | 351.11 | 78% | | E5 | GRN | 8.43 | 346.2 | 345.18 | 65% | | E6 | SHE | 8.68 | 372.17 | 371.14 | 76% | | E7 | SQE | 8.45 | 363.17 | 362.14 | 67% | | E8 | SMH | 9.46 | 374.26 | 373.14 | 75% | | E9 | ARM | 8.03 | 377.6 | 376.19 | 77% | | E10 | AQE | 9.97 | 347.0 | 346.15 | 76% |
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tR: peptide retention time.
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