Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors

Table 2

COXs theoretical binding energies (be) in kcal/mol, number of van der Waals interacting enzyme residues (ir), and intermolecular hydrogen bonds (hb).

Peptide	COX-1			COX-2
	be	ir	hb	be	ir	hb
GMD	−1.20	23	1	−39.87	21	3
GHE	−0.56	25	0	−42.15	26	5
YYV	—	—	—	—	—	—