Ischemia Induces Release of Endogenous Amino Acids from the Cerebral Cortex and Cerebellum of Developing and Adult Mice

Figure 3

Time course of basal (-○-) and K⁺-evoked (-⚫-) taurine release from cerebral cortical slices in normoxia and basal (-∆-) and K⁺-stimulated (-▴-) taurine release in ischemia in 7-day-old (a) and 3-month-old (b) mice. The results are means of 4–8 independent experiments with SEMs indicated. Ischemia significantly (𝑃<0.01) enhanced the release in both age groups, but K⁺ stimulation was similarly effective only in normoxia, the effect being less pronounced (𝑃<0.05) in ischemia. Note the 2.5-fold difference in the scale of the 𝑦-axis in panels (a) and (b).

(a)

(b)