Table of Contents
Journal of Amino Acids
Volume 2013 (2013), Article ID 964637, 6 pages
http://dx.doi.org/10.1155/2013/964637
Clinical Study

Ingestion of Leucine + Phenylalanine with Glucose Produces an Additive Effect on Serum Insulin but Less than Additive Effect on Plasma Glucose

1Endocrinology, Metabolism, and Nutrition Section, Minneapolis VA Health Care System, One Veterans Drive, Minneapolis, MN 55417, USA
2Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
3Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA

Received 19 December 2012; Revised 26 March 2013; Accepted 10 April 2013

Academic Editor: Imre Sovago

Copyright © 2013 Jennifer F. Iverson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. C. Gannon and F. Q. Nuttall, “Amino acid ingestion and glucose metabolism—a review,” IUBMB Life, vol. 62, no. 9, pp. 660–668, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Kalogeropoulou, L. Lafave, K. Schweim, M. C. Gannon, and F. Q. Nuttall, “Leucine, when ingested with glucose, synergistically stimulates insulin secretion and lowers blood glucose,” Metabolism, vol. 57, no. 12, pp. 1747–1752, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Q. Nuttall, K. J. Schweim, and M. C. Gannon, “Effect of orally administered phenylalanine with and without glucose on insulin, glucagon and glucose concentrations,” Hormone and Metabolic Research, vol. 38, no. 8, pp. 518–523, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. S. S. Fajans, J. C. Floyd, R. F. Knopf, and F. W. Conn, “Effect of amino acids and proteins on insulin secretion in man,” Recent Progress in Hormone Research, vol. 23, pp. 617–662, 1967. View at Google Scholar · View at Scopus
  5. M. J. MacDonald, L. A. Fahien, L. J. Brown, N. M. Hasan, J. D. Buss, and M. A. Kendrick, “Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion,” American Journal of Physiology, vol. 288, no. 1, pp. E1–E15, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. L. A. Fahien and M. J. Macdonald, “The complex mechanism of glutamate dehydrogenase in insulin secretion,” Diabetes, vol. 60, pp. 2450–2454, 2011. View at Google Scholar
  7. R. Landgraf, M. M. Landgraf-Leurs, and R. Hoerl, “L-leucine and l-phenylalanine induced insulin release and the influence of d-glucose. Kinetic studies with the perfused rat pancreas,” Diabetologia, vol. 10, no. 5, pp. 415–420, 1974. View at Google Scholar · View at Scopus
  8. T. A. Chatterton, C. H. Reynolds, N. R. Lazarus, and C. I. Pogson, “The role of phosphoenolpyruvate in insulin secretion: the effect of l-phenylalanine,” Experientia, vol. 40, no. 12, pp. 1426–1427, 1984. View at Google Scholar · View at Scopus
  9. F. Reimann, L. Williams, G. D. Xavier, G. A. Rutter, and F. M. Gribble, “Glutamine potently stimulates glucagon-like peptide-1 secretion from glutag cells,” Diabetologia, vol. 47, no. 9, pp. 1592–1601, 2004. View at Publisher · View at Google Scholar · View at Scopus