Table of Contents
Journal of Amino Acids
Volume 2014, Article ID 721291, 14 pages
http://dx.doi.org/10.1155/2014/721291
Research Article

Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids

1Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd., Plot No. 28, IDA, Nacharam, Hyderabad, Andhra Pradesh 500 076, India
2Centre for Chemical Sciences & Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Andhra Pradesh 500 072, India

Received 26 June 2014; Accepted 14 October 2014; Published 19 November 2014

Academic Editor: Sambasivarao Kotha

Copyright © 2014 P. Ravi Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new series of isoxazole tethered quinone-amino acid hybrids has been designed and synthesized involving 1,3-dipolar cycloaddition reaction followed by an oxidation reaction using cerium ammonium nitrate (CAN). Using this method, for the first time various isoxazole tethered quinone-phenyl alanine and quinone-alanine hybrids were synthesized from simple commercially available 4-bromobenzyl bromide, propargyl bromide, and 2,5-dimethoxybenzaldehyde in good yield.