Table of Contents
Journal of Amino Acids
Volume 2015, Article ID 481517, 8 pages
Research Article

The Association of Endothelin-1 with Markers of Arterial Stiffness in Black South African Women: The SABPA Study

1Hypertension in Africa Research Team (HART), North-West University, Potchefstroom 2531, South Africa
2Medical Research Council, Research Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa

Received 15 October 2015; Revised 26 November 2015; Accepted 1 December 2015

Academic Editor: Hieronim Jakubowski

Copyright © 2015 Christine Susara du Plooy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Limited data exist regarding endothelin-1 (ET-1), a vasoactive contributor in vascular tone, in a population subjected to early vascular deterioration. We compared ET-1 levels and explored its association with markers of arterial stiffness in black and white South Africans. Methodology. This cross-sectional substudy included 195 black (men: ; women: ) and 197 white (men: ; women: ) South Africans. Serum ET-1 levels were measured as well as markers of arterial stiffness (blood pressure, pulse wave velocity, and arterial compliance). ET-1 levels were higher in black men and white women compared to their counterparts after adjusting for C-reactive protein. In both single and partial (adjusting for body mass index and gamma glutamyl transferase) regression analyses ET-1 correlated with age, interleukin-6, high density lipoprotein cholesterol, systolic blood pressure, pulse pressure, and pulse wave velocity in black women. In multivariate regression analyses the independent association of ET-1 with systolic blood pressure (Adj. ; , ) and pulse pressure (Adj. ; , ) was confirmed in black women only. ET-1 additionally associated with interleukin-6 in black women (). Conclusion. Our result suggests that ET-1 and its link with subclinical arteriosclerosis are potentially driven by low-grade inflammation as depicted by the association with interleukin-6 in the black female cohort.