Journal of Amino Acids

Functional Residues in Proteins


Publishing date
15 Aug 2011
Status
Published
Submission deadline
15 Feb 2011

1National Institute of Biomedical Innovation, Osaka, Japan

2Department of Multimedia and Game Science, Lunghwa University of Science and Technology, Guishan, Taoyuan County, Taiwan

3Depatment of Biology, Alabama A&M University, Normal, AL 35762, USA

4Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia (Central University), New Delhi, India


Functional Residues in Proteins

Description

Primary structure of proteins is made of thousands of amino acid residues, yet only a very small region seems to play a role in most of its function. This region is often called “binding site,” “active site,” or “catalytic site” depending on the context and the type of function associated with it. An amino acid residue in protein is not only its compositional alphabet but also serves as a minimal unit of mutations and source of its stability and functional diversity. It is amazing how changes as small as one or a few key residues can bring about qualitative changes in the cellular functions of organisms, and hence it becomes essential to identify these residues and understand their role in structure and function, as well as the mechanism of their action. A lot of experimental and computational research in biology is devoted to the identification of these so‐called functional residues. Yet, the process of finding functional residues remains incomplete in terms of both experimental discovery as well as predictive strategies. In this special issue, we invite papers reporting results from experimental as well as computational studies, which help us in identifying functional residues in proteins. Potential topics include, but are not limited to:

  • Functional residues in single proteins, such as enzymes, and protein‐protein, protein nucleic acid, and protein ligand complexes
  • Effect of mutations on structure and function of single proteins, their multimers, and large assemblies
  • Cooperativity between residues and discovery of sequence and structural motifs
  • Evolutionary dynamics, conservation, and functional diversity of amino acid residues
  • Amino acid alphabet, information, and entropy in protein sequences and structures
  • Thermodynamics and calorimetric studies on functional residues, for example, binding sites and active sites
  • Prediction of binding sites, active sites, or residues which are important for function and structure

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jaa/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 606354
  • - Editorial

Functional Residues in Proteins

Shandar Ahmad | Jung-Ying Wang | ... | Faizan Ahmad
  • Special Issue
  • - Volume 2011
  • - Article ID 812540
  • - Review Article

The Dynamic Structure of the Estrogen Receptor

Raj Kumar | Mikhail N. Zakharov | ... | Ravi Jasuja
  • Special Issue
  • - Volume 2011
  • - Article ID 207691
  • - Review Article

Small Changes Huge Impact: The Role of Protein Posttranslational Modifications in Cellular Homeostasis and Disease

Tejaswita M. Karve | Amrita K. Cheema
  • Special Issue
  • - Volume 2011
  • - Article ID 785741
  • - Review Article

Role of Charged Residues in the Catalytic Sites of Escherichia coli ATP Synthase

Zulfiqar Ahmad | Florence Okafor | Thomas F. Laughlin
  • Special Issue
  • - Volume 2011
  • - Article ID 843206
  • - Review Article

Functional Subunits of Eukaryotic Chaperonin CCT/TRiC in Protein Folding

M. Anaul Kabir | Wasim Uddin | ... | Zulfiqar Ahmad
  • Special Issue
  • - Volume 2011
  • - Article ID 606797
  • - Review Article

Serpin Inhibition Mechanism: A Delicate Balance between Native Metastable State and Polymerization

Mohammad Sazzad Khan | Poonam Singh | ... | Mohamad Aman Jairajpuri
  • Special Issue
  • - Volume 2011
  • - Article ID 574816
  • - Review Article

Metal Preferences of Zinc-Binding Motif on Metalloproteases

Kayoko M. Fukasawa | Toshiyuki Hata | ... | Junzo Hirose
  • Special Issue
  • - Volume 2011
  • - Article ID 531412
  • - Review Article

Functionally Relevant Residues of Cdr1p: A Multidrug ABC Transporter of Human Pathogenic Candida albicans

Rajendra Prasad | Monika Sharma | Manpreet Kaur Rawal
  • Special Issue
  • - Volume 2011
  • - Article ID 709404
  • - Review Article

Catalytic Site Cysteines of Thiol Enzyme: Sulfurtransferases

Noriyuki Nagahara
  • Special Issue
  • - Volume 2011
  • - Article ID 352538
  • - Review Article

The Catalytic Machinery of a Key Enzyme in Amino Acid Biosynthesis

Ronald E. Viola | Christopher R. Faehnle | ... | Alexander G. Pavlovsky

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