Journal of Amino Acids

Bioactive Peptides in Cancer: Therapeutic Use and Delivery Strategies


Publishing date
10 May 2013
Status
Published
Submission deadline
21 Dec 2012

1Department of Biochemistry and Biophysics, Second University of Naples, Naples, Italy

2Department of Pharmaceutical Chemistry and Toxicology, University of Naples Federico II, Via Montesano 49, 80131 Naples, Italy

3Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA


Bioactive Peptides in Cancer: Therapeutic Use and Delivery Strategies

Description

Human cancer is one of the most important causes of death in the western countries. In advanced stages of the disease, the therapeutic opportunities are still limited due to the difficulty to target specifically only cancer cells sparing healthy ones. Cancer cells have on their surface antigens that are expressed at higher levels than their normal counterparts. Often these antigens (also called tumour-associated antigens) have receptor activity and bind to specific proteins or peptides. The latter can be used for the specific delivery of anticancer drugs to cancer cells through retargeting strategies and/or for the direct modulation of cancer cell proliferation and survival interacting with cell-surface-specific receptors.

These bioactive peptides can be raised against either tumour cells themselves or to the tumour microenvironment cell components (tumour vessels, tumour-associated macrophages, and fibroblasts). However, the feasibility of pharmacological application of peptides depends on absorption and bioavailability in intact forms in target tissues. Moreover, their correct biodistribution is sometimes hampered by biopharmaceutical drawbacks, that is, protection by circulating protease-mediated degradation or specific accumulation in tumour tissues. Chemical modification of peptide backbone can increase the stability of peptides in biological fluids. Moreover, the use of delivery systems, and in particular the use of nanotechnologies, not only protects peptides from enzymatic degradation but also improves the delivery of the bioactive peptide in the target tissue. Moreover, peptide conjugation on the surface of nanovectors can be useful for selective delivery of conventional chemotherapeutic agents in tumour tissues.

Therefore, we invite investigators to contribute original research articles as well as review articles in the following potential topics. Potential topics include, but are not limited to:

  • Biopharmaceutical issues for peptide administration (enzymatic degradation, nonspecific distribution in the body, and physical and chemical instability)
  • Chemical modification of the peptides (modified amino acids and polymeric conjugation)
  • Drug delivery systems for peptides
  • Peptides as targeting moieties

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jaa/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/jaa/bioapp/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 568953
  • - Editorial

Bioactive Peptides in Cancer: Therapeutic Use and Delivery Strategies

Paola Stiuso | Michele Caraglia | ... | Antonio Giordano
  • Special Issue
  • - Volume 2013
  • - Article ID 509056
  • - Research Article

DTNQ-Pro, a Mimetic Dipeptide, Sensitizes Human Colon Cancer Cells to 5-Fluorouracil Treatment

Isabel Gomez-Monterrey | Pietro Campiglia | ... | Paola Stiuso
  • Special Issue
  • - Volume 2013
  • - Article ID 178381
  • - Research Article

Amino Acid Derivatives as New Zinc Binding Groups for the Design of Selective Matrix Metalloproteinase Inhibitors

Mariateresa Giustiniano | Paolo Tortorella | ... | Alfonso Carotenuto
  • Special Issue
  • - Volume 2013
  • - Article ID 606282
  • - Research Article

Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors

Ermelinda Vernieri | Isabel Gomez-Monterrey | ... | Pietro Campiglia
  • Special Issue
  • - Volume 2013
  • - Article ID 939804
  • - Review Article

Potential Anticarcinogenic Peptides from Bovine Milk

Giacomo Pepe | Gian Carlo Tenore | ... | Pietro Campiglia
  • Special Issue
  • - Volume 2013
  • - Article ID 979016
  • - Review Article

Urotensin-II Ligands: An Overview from Peptide to Nonpeptide Structures

Francesco Merlino | Salvatore Di Maro | ... | Paolo Grieco
  • Special Issue
  • - Volume 2013
  • - Article ID 251398
  • - Research Article

The Antitumor Peptide CIGB-552 Increases COMMD1 and Inhibits Growth of Human Lung Cancer Cells

Julio R. Fernández Massó | Brizaida Oliva Argüelles | ... | Maribel G. Vallespí
  • Special Issue
  • - Volume 2012
  • - Article ID 967347
  • - Review Article

Cancer Treatment Using Peptides: Current Therapies and Future Prospects

Jyothi Thundimadathil