Table of Contents
Journal of Applied Chemistry
Volume 2014 (2014), Article ID 325627, 9 pages
http://dx.doi.org/10.1155/2014/325627
Research Article

Investigation of Regenerated Cellulose/Poly(acrylic acid) Composite Films for Potential Wound Healing Applications: A Preliminary Study

Polymer Research Laboratory, Department of Chemistry, Government Model Science College, Jabalpur 482001, India

Received 20 January 2014; Revised 14 March 2014; Accepted 17 March 2014; Published 6 May 2014

Academic Editor: Alejandro Rodriguez

Copyright © 2014 Manjula Bajpai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Regenerated cellulose/poly(acrylic acid) composite films have been synthesized for wound dressing applications. The water absorbency of these films was studied as a function of amount of cross-linker N,N′-methylenebisacrylamide and cellulose contents in the feed mixture. The samples, having different compositions, showed tensile strength and percent elongation in the range of to  N/m2 and 110 to 265, respectively. The water vapor transmission rate (WVTR) for various films was found to be in the range of 2.03 to 7.18 mg/cm2/h. These films were loaded with antibacterial drug miconazole nitrate and their release was studied in the physiological pH at 37°C. The release data was found to fit well the diffusion controlled Higuchi model. Finally the films demonstrated fair antibacterial and antifungal action, thus establishing their strong candidature as wound dressing materials.