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Journal of Applied Chemistry
Volume 2015 (2015), Article ID 743094, 7 pages
Research Article

Proficient Procedure for Preparation of Quinoline Derivatives Catalyzed by NbCl5 in Glycerol as Green Solvent

Department of Chemistry, College of Sciences, University of Birjand, Birjand 97175-615, Iran

Received 30 August 2014; Revised 14 December 2014; Accepted 15 December 2014

Academic Editor: Hongxing Dai

Copyright © 2015 Mohammad Ali Nasseri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Quinolines, an important class of potentially bioactive compounds, have been synthesized by treatment of o-aminoaryl ketones and carbonyl compound utilizing niobium (V) chloride (NbCl5) as an available and inexpensive catalyst. The quinoline derivatives were prepared in glycerol, an excellent solvent in terms of environmental impact, with high yields (76–98%) and short reaction times (20–90 min). Not only diketones but also ketones afforded the desired products in good to excellent yields. The reaction time of 2-amino-5-chlorobenzophenone and dicarbonyl compounds was longer than that of 2-aminobenzophenone. The reaction of cyclic diketones took place faster than open chain analogues. These reactions also proceeded with acetophenone derivatives. In these cases the reaction times are longer.