Saccharomyces cerevisiae Catalyzed Cyclocondensation Reaction: Synthesis of Pyrazoline

Table 3

Baker’s yeast catalyzed synthesis of pyrazoline derivatives in organic solvent.

S. N.	R1	R2	Product	Yield (%)
1	H	H	3a	86
2	H	4-Cl	3b	88
3	H	4-NO2	3c	82
4	H	4-N(CH3)	3d	86
5	H	4-OCH3	3e	78
6	4-OH	H	3f	75
7	4-OH	4-Cl	3g	76
8	4-OH	4-OCH3	3h	84
9	2-OH	H	3i	78
10	2-OH	4-N(CH3)2	3j	82
11	2-OH	4-Cl	3k	78
12	3,4 OCH3	H	3l	68
13	3,4 OCH3	4-Cl	3m	66

Reaction condition: chalcone (5 mmol), hydrazine hydrate (10 mmol), and baker’s yeast (2 g) in methanol (15 mL) under room temperature at 32 h. Isolated yield.