Figure 1: Experimental timeline for U50,488-induced reinstatement testing. Rats () were trained to self-administer ethanol, and then lever pressing was extinguished. Following extinction rats were injected with U50,488 (0.1–10 mg/kg, i.p.) or saline 10 minutes prior to testing. Tests were conducted every 3-4 days, with rats experiencing extinction sessions daily between test days.