Table of Contents
Journal of Artificial Evolution and Applications
Volume 2009 (2009), Article ID 848532, 13 pages
http://dx.doi.org/10.1155/2009/848532
Research Article

Classification of Oncologic Data with Genetic Programming

1Department of Informatics, Systems and Communication (D.I.S.Co.), University of Milano-Bicocca, 20126 Milan, Italy
2Consorzio Milano Ricerche, 20126 Milan, Italy

Received 14 November 2008; Revised 2 April 2009; Accepted 13 June 2009

Academic Editor: Jason Moore

Copyright © 2009 Leonardo Vanneschi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Discovering the models explaining the hidden relationship between genetic material and tumor pathologies is one of the most important open challenges in biology and medicine. Given the large amount of data made available by the DNA Microarray technique, Machine Learning is becoming a popular tool for this kind of investigations. In the last few years, we have been particularly involved in the study of Genetic Programming for mining large sets of biomedical data. In this paper, we present a comparison between four variants of Genetic Programming for the classification of two different oncologic datasets: the first one contains data from healthy colon tissues and colon tissues affected by cancer; the second one contains data from patients affected by two kinds of leukemia (acute myeloid leukemia and acute lymphoblastic leukemia). We report experimental results obtained using two different fitness criteria: the receiver operating characteristic and the percentage of correctly classified instances. These results, and their comparison with the ones obtained by three nonevolutionary Machine Learning methods (Support Vector Machines, MultiBoosting, and Random Forests) on the same data, seem to hint that Genetic Programming is a promising technique for this kind of classification.