Empirical Likelihood Estimation for Population Pharmacokinetic Study Based on Generalized Linear Model

Table 1

Means of parameter estimates for 𝛽 with its standard derivation (SD) and mean length (ML) of the confidence region, when the estimation method are empirical likelihood (EL) and general estimation equation (GEE), respectively.

𝑛	EL		GEE
	Mean	CI (95% level)	Mean	CI (95% level)
10	0.8001	(0.7851, 0.8151)	0.8001	(0.7834, 0.8177)
	−0.0398	(−0.0414, −0.0382)	−0.0398	(−0.0420, −0.0378)
	−0.2003	(−0.2049, −0.1956)	−0.2003	(−0.2059, −0.1946)
50	0.8001	(0.7951, 0.8051)	0.8001	(0.7841, 0.8160)
	−0.0401	(−0.0405, −0.0395)	−0.0401	(−0.0410, −0.0389)
	−0.2000	(−0.2016, −0.1984)	−0.2000	(−0.2029, −0.1973)
100	0.8001	(0.7966, 0.8036)	0.8001	(0.7908, 0.8094)
	−0.0400	(−0.0403, −0.0397)	−0.0400	(−0.0404, −0.0395)
	−0.2000	(−0.2011, −0.1989)	−0.2000	(−0.2023, −0.1984)