Table of Contents Author Guidelines Submit a Manuscript
Journal of Applied Mathematics
Volume 2013 (2013), Article ID 378253, 13 pages
http://dx.doi.org/10.1155/2013/378253
Research Article

Design and Simulation of a Fused Silica Space Cell Culture and Observation Cavity with Microfluidic and Temperature Controlling

Shangchun Fan,1,2,3 Jinhao Sun,1,2,3 Weiwei Xing,1,2,3 Cheng Li,1,2,3 and Dongxue Wang1,2,3

1School of Instrument Science and Opto-Electronics Engineering, Beihang University, 37 Xueyuan Road, Haidian District, Beijing 100191, China
2Key Laboratory of Precision Opto-Mechatronics Technology, Ministry of Education, Beihang University, Beijing 100191, China
3Key Laboratory of Inertial Science and Technology for National Defence, Beihang University, Beijing 100191, China

Received 11 June 2013; Accepted 27 September 2013

Academic Editor: Bo Yu

Copyright © 2013 Shangchun Fan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. van der Schoot, M. Boillat, and N. de Rooij, “Micro-instruments for life science research,” IEEE Transactions on Instrumentation and Measurement, vol. 50, no. 6, pp. 1538–1542, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. I. Walther, B. van der Schoot, M. Boillat, and A. Cogoli, “Performance of a miniaturized bioreactor in space flight: microtechnology at the service of space biology,” Enzyme and Microbial Technology, vol. 27, no. 10, pp. 778–783, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. V. D. Kern, S. Bhattacharya, R. N. Bowman et al., “Life sciences flight hardware are development for the international space station,” Advances in Space Research, vol. 27, no. 5, pp. 1023–1030, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. Commercial Generic Bioprocessing Apparatus (CGBA) [EB/OL], 2009, http://www.nasa.gov/centers/marshall/news/background/facts/cgba.html.
  5. Y. Tan, X. G. Yuan, J. B. Rui, and J. R. Yu, “Research progress of cell culture apparatus,” Space Medicine & Medical Engineering, vol. 15, no. 5, pp. 383–386, 2002. View at Google Scholar · View at Scopus
  6. M. Huang, S. Fan, W. Xing, and C. Liu, “Microfluidic cell culture system studies and computational fluid dynamics,” Mathematical and Computer Modelling, vol. 52, no. 11-12, pp. 2036–2042, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Hu, X. Zhang, J. Yang, S. W. Joo, and S. Qian, “A cell electrofusion microfluidic chip with micro-cavity microelectrode array,” Microfluidics and Nanofluidics, vol. 15, no. 2, pp. 151–160, 2013. View at Publisher · View at Google Scholar
  8. K. Lei, M. H. Wu, P. Y. Liao, Y. M. Chen, and T. M. Pan, “Development of a micro-scale perfusion 3D cell culture biochip with an incorporated electrical impedance measurement scheme for the quantification of cell number in a 3D cell culture construct,” Microfluidics and Nanofluidics, vol. 12, no. 1–4, pp. 117–125, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Sharma, A. R. B. Moniz, I. Triantis et al., “An integrated silicon sensor with microfluidic chip for monitoring potassium and pH,” Microfluidics and Nanofluidics, vol. 10, no. 5, pp. 1119–1125, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. S. K. Yoo, J. H. Lee, S. S. Yun, M. B. Gu, and J. H. Lee, “Fabrication of a bio-MEMS based cell-chip for toxicity monitoring,” Biosensors and Bioelectronics, vol. 22, no. 8, pp. 1586–1592, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. B. S. Elkins, M. Huang, and J. I. Frankel, “Higher-time derivative of in-depth temperature sensors for aerospace heat transfer,” International Journal of Thermal Sciences, vol. 52, pp. 31–39, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. F. Vallez-Chetreanu, L. G. Fraisse Ferreira, R. Rabe, U. von Stockar, and I. W. Marison, “An on-line method for the reduction of fouling of spin-filters for animal cell perfusion cultures,” Journal of Biotechnology, vol. 130, no. 3, pp. 265–273, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Voisard, F. Meuwly, P. A. Ruffieux, G. Baer, and A. Kadouri, “Potential of cell retention techniques for large-scale high-density perfusion culture of suspended mammalian cells,” Biotechnology and Bioengineering, vol. 82, no. 7, pp. 751–765, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. B. J. Klement and B. S. Spooner, “Utilization of microgravity bioreactors for differentiation of mammalian skeletal tissue,” Journal of Cellular Biochemistry, vol. 51, no. 3, pp. 252–256, 1993. View at Publisher · View at Google Scholar · View at Scopus
  15. I. Walther, B. van der Schoot, M. Boillat, and A. Cogoli, “Performance of a miniaturized bioreactor in space flight: microtechnology at the service of space biology,” Enzyme and Microbial Technology, vol. 27, no. 10, pp. 778–783, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Yi, C. W. Li, S. Ji, and M. Yang, “Microfluidics technology for manipulation and analysis of biological cells,” Analytica Chimica Acta, vol. 560, no. 1-2, pp. 1–23, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. J. H. Yeon and J. K. Park, “Microfluidic cell culture systems for cellular analysis,” Biochip Journal, vol. 1, no. 1, pp. 17–27, 2007. View at Google Scholar
  18. J. El-Ali, P. K. Sorger, and K. F. Jensen, “Cells on chips,” Nature, vol. 442, no. 7101, pp. 403–411, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Kim, Y. C. Toh, J. Voldman, and H. Yu, “A practical guide to microfluidic perfusion culture of adherent mammalian cells,” Lab on a Chip, vol. 7, no. 6, pp. 681–694, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. D. W. Hutmacher and H. Singh, “Computational fluid dynamics for improved bioreactor design and 3D culture,” Opinion Trends in Biotechnology, vol. 26, no. 2, pp. 166–172, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Singh, S. H. Teoh, H. T. Low, and D. W. Hutmacher, “Flow modelling within a scaffold under the influence of uni-axial and bi-axial bioreactor rotation,” Journal of Biotechnology, vol. 119, no. 2, pp. 181–196, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. W. Xia, S. Fan, W. Xing, C. Liu, T. Li, and J. Wang, “A mathematical morphological approach for region of interest coding of microscopy image compression,” Journal of Harbin Institute of Technology, vol. 19, no. 3, pp. 115–121, 2012. View at Google Scholar