A Dynamic Model of PI3K/AKT Pathways in Acute Myeloid Leukemia

Table 2

Parameter values and kinetic rates being used.

Parameter	Description	Unit	Value	References
	PI3K level		0.01 – 0.1	[21]
	Increase activation PIP3 by FOXO3ap		0.0083
	Constant rate of PIP3 dephosphorylation by PTEN		0.0006 – 0.21	[21]
	PIP3 degradation		0.001 – 0.01	[22]
	AKT production rate		0.036 – 0.108	[21, 22]
	Constant rate of AKT phosphorylation		1 – 20	[21]
	Constant rates of AKTp dephosphorylation by PP2A		0.36 – 13.5	[21, 22]
	AKT degradation rate		0.063 – 0.08	[21]
	AKTp degradation rate		0.0008 – 0.1	[21, 22]
	FOXO3a production rate		0.002 – 0.5
	FOXO3a degradation rate by 14-3-3 protein		0.004 – 0.28
	Constant rate of FOXO3a phosphorylation		0 – 0.33
	Constant rate of FOXO3a dephosphorylation by PP2A		0.000297 – 2.92
	FOXO3ap degradation rate		0.033 – 0.125
	Michaelis constant of PIP3 dephosphorylation		0.01 – 1	[18, 20]
	Michaelis constant of AKT phosphorylation		0.1	[20]
	Michaelis constant of AKTp dephosphorylation		0.08 – 0.4	[20, 22]
	Michaelis constant of FOXO3a phosphorylation		0.1
	Michaelis constant of FOXO3ap dephosphorylation		0.1

Parameters values are assumed to be the same as other transcription factors such as MDM2 in [18, 22].