Plasma amino-acid determinations by reversed-phase HPLC: Improvement of the
orthophthalaldehyde method and comparison with ion exchange chromatography

Ziegler, Frédéric; Le Boucher, Jacques; Coudray-Lucas, Colette; Cynober, Luc

doi:https://doi.org/10.1155/S1463924692000270

Journal of Analytical Methods in Chemistry

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Volume 14 | Article ID 168020 | https://doi.org/10.1155/S1463924692000270

Plasma amino-acid determinations by reversed-phase HPLC: Improvement of the orthophthalaldehyde method and comparison with ion exchange chromatography

Frédéric Ziegler,¹Jacques Le Boucher,¹Colette Coudray-Lucas,¹and Luc Cynober^1,2

Abstract

RP-HPLC with automated pre-column OPA derivatization is clearly a suitable alternative for assaying physiological AA and may be particularly useful for AA present at low concentrations (free tryptophan, plasma 3-methylhistidine).

Copyright

Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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