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Journal of Automatic Chemistry
Volume 16, Issue 1, Pages 33-42

Development of fully-automated synthesis systems

Molecular Chemistry Laboratory, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd, 17–85, uso Honmachi 2-chome, Todogawa-ku, Osaka 532, Japan

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper describes the development of fully-automated synthesis systems for preparing and isolating various kinds of pharmaceutical compounds. The systems are versatile, and are able to perform most of the chemical reactions currently used in organic chemistry, with the exception of hydrogenation which requires high pressure. An additional benefit is the very user-friendly software.