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Journal of Automatic Chemistry
Volume 16, Issue 2, Pages 63-66

Enzyme reference materials: their place in diagnostic enzyrnology

Rqal Postgraduate Medical School, Hammersmith Hospital, London W12 ONN, UK

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Estimations of the activities of various enzymes in clinical samples are routine tasks for clinical chemists. Most of this work is done by automatic analysis. The reference ranges against which patients' results are interpreted, however, have generally been defined in terms of manual methods and the conditions of a manual method cannot be reproduced in automated systems. This paper describes the possibility of translating the results of enzyme analysis into a common currency through the use of enzyme reference materials as calibrators.