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Journal of Automatic Chemistry
Volume 17 (1995), Issue 3, Pages 109-114

Automated synthesis of radiopharmaceuticals for positron emission tomography: an apparatus for [1-11C] labeled carboxylic acid

Institute for Biofunctional Research, c/o National Cardiovascular Center, 7-15-Chome, Fujishiro-Dai, Suita City, Osaka 565, Japan

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A fully automated apparatus for the synthesis and formulation of short-lived 11C (t1/2 = 20 min)-labeled carboxylic acids for positron emission tomograpy (PET) has been developed. Injectable solutions of [1-11C]acetic acid, [1-11C]octanoic acid and [1-11C]palmitic acid wilh radioactivities of 6.36-8.29 GBq, 0.070-1.43 GBq and 0.42-0.89 GBq were obtained. The preparation time was under 40 min after the end of bombardment. An automatic washing function means that labeled compound of the same or different kinds can be produced several times a day without any maintenance of the system. The control system is sited away from the ‘hot laboratory’, so operator exposure to radiation is minimized.