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Journal of Automated Methods and Management in Chemistry
Volume 2006, Article ID 39325, 7 pages
http://dx.doi.org/10.1155/JAMMC/2006/39325

Evaluation of Innotrac Aio! Second-Generation Cardiac Troponin I Assay: The Main Characteristics for Routine Clinical Use

1Laboratory of Oulu University Hospital, Department of Clinical Chemistry, University of Oulu, P.O. Box 500, Oulu 90029, Finland
2Emergency Unit, Department of Internal Medicine, Oulu University Hospital, Oulu 90029, Finland
3Kuusamo Hospital Laboratory, Kuusamo 93600, Finland
4Division of Nephrology, Department of Internal Medicine, Oulu University Hospital, Oulu 90029, Finland
5Division of Cardiology, Department of Internal Medicine, Oulu University Hospital, Oulu 90029, Finland
6Division of Rheumatology, Department of Internal Medicine, Oulu University Hospital, Oulu 90029, Finland

Received 30 October 2005; Revised 7 February 2006; Accepted 13 February 2006

Copyright © 2006 P. Hedberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. The Joint European Society of Cardiology/ American College of Cardiology Committee, “Myocardial infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction,” Journal of the American College of Cardiology, vol. 36, no. 3, pp. 959–969, 2000. View at Publisher · View at Google Scholar
  2. “ACC/AHA guidelines for the management of patients with unstable angina and non-ST segment elevation myocardial infarction: executive summary and recommendations. A report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients with Unstable Angina),” Circulation, vol. 102, pp. 1893–1900, 2000.
  3. K. Petterson, T. Katajamäki, K. Irjala, V. Leppänen, K. Majamaa-Voltti, and P. Laitinen, “Time-resolved fluorometry (TRF)-based immunoassay concept for rapid and quantitative determination of biochemical myocardial infarction markers from whole blood, serum and plasma,” Luminescence, vol. 15, no. 6, pp. 399–407, 2000. View at Publisher · View at Google Scholar
  4. T. Lövren, L. Meriö, K. Mitrunen et al., “One-step all-in-one dry reagent immunoassays with fluorescent Europium chelate label and time-resolved fluorometry,” Clinical Chemistry, vol. 42, no. 8 pt 1, pp. 1196–1201, 1996. View at Google Scholar
  5. P. Hedberg, J. Kurittu, and M. Puukka, “Evaluation of the new Innotrac Aio! 2nd generation cardiac troponin I assay,” Clinical Chemistry and Laboratory Medicine, vol. 41, no. supplement W-125, p. S426, 2003. View at Google Scholar
  6. F. Pagani, F. Stefini, and M. Panteghini, “Innotrac Aio! second-generation cardiac troponin I assay: Imprecision profile and other key characteristics for clinical use,” Clinical Chemistry, vol. 50, pp. 1271–1272, 2004. View at Publisher · View at Google Scholar
  7. A. Dasgupta, S. Banerjee, and P. Datta, “False-positive troponin I in the MEIA due to the presence of rheumatoid factors in serum. Elimination of this interference by using a polyclonal antisera against rheumatoid factors,” American Journal of Clinical Pathology, vol. 112, no. 6, pp. 753–756, 1999. View at Google Scholar
  8. A. Katrukha, A. Bereznikova, V. Filatov et al., “Degradation of cardiac troponin I: implication for reliable immunodetection,” Clinical Chemistry, vol. 44, no. 12, pp. 2433–2440, 1998. View at Google Scholar
  9. A. Katrukha, A. Bereznikova, V. Filatov, and T. Esakova, “Biochemical factors influencing measurement of cardiac troponin I in serum (Review),” Clinical Chemistry and Laboratory Medicine, vol. 37, no. 11-12, pp. 1091–1095, 1999. View at Publisher · View at Google Scholar
  10. A. Katrukha, A. Bereznikova, T. Esakova et al., “Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex,” Clinical Chemistry, vol. 43, pp. 1379–1385, 1997. View at Google Scholar
  11. M. Panteghini, W. Gerhardt, F. S. Apple, F. Dati, J. Ravkilde, and A. H. Wu, “Quality specifications for cardiac troponin assays,” Clinical Chemistry and Laboratory Medicine, vol. 39, no. 2, pp. 175–179, 2001. View at Publisher · View at Google Scholar
  12. S. Eriksson, M. Junikka, P. Laitinen, K. Majamaa-Voltti, H. Alfthan, and K. Pettersson, “Negative interference in cardiac troponin I immunoassays from a frequently occuring serum and plasma component,” Clinical Chemistry, vol. 49, no. 7, pp. 1095–1104, 2003. View at Publisher · View at Google Scholar
  13. Z. Zaman, S. De Spiegeleer, M. Gerits, and N. Blanckaert, “Analytical and clinical performance of two cardiac troponin I immunoassays,” Clinical Chemistry and Laboratory Medicine, vol. 37, no. 9, pp. 889–897, 1999. View at Publisher · View at Google Scholar
  14. K. S. Quinn-Hall, S. W. Bateman, A. H. Wu, S. Wieczorek, G. A. Ficher, and K. T. Yeo, “Functional sensitivity of cardiac troponin assays and implications for risk stratification (Absract),” Clinical Chemistry, vol. 46, no. supplement 6, p. A78, 2000. View at Google Scholar
  15. P. Hedberg, J. Valkama, and M. Puukka, “Analytical performance of time-resolved fluorometry-based Innotrac Aio! cardiac marker immunoassays,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 63, no. 1, pp. 55–64, 2003. View at Publisher · View at Google Scholar
  16. W. Gerhardt, G. Nordin, A. Herbert et al., “Troponin T and I assays show decreased concentrations in heparin plasma compared with serum: Lower recoveries in early than in late phase of myocardial injury,” Clinical Chemistry, vol. 46, pp. 817–821, 2000. View at Google Scholar