Research Article | Open Access
Xin Yu Jiang, Xiao Qing Chen, Zheng Dong, Ming Xu, "The Application of Resonance Light Scattering Technique for the Determination of Tinidazole in Drugs", Journal of Analytical Methods in Chemistry, vol. 2007, Article ID 086857, 7 pages, 2007. https://doi.org/10.1155/2007/86857
The Application of Resonance Light Scattering Technique for the Determination of Tinidazole in Drugs
A resonance light scattering technique to determine tinidazole in drugs was developed by tetraphenylboron sodium (TPB). Tinidazole was found to bind anion and transformed to tinidazole-TPB aggregate which displayed intense resonance scattering light. Effects of factors such as wavelength, acidity, stabilizers, and interferents on the RLS of tinidazole TPB were investigated in detail. The RLS intensity of the tinidazole-TPB suspension was obtained in sulfuric acid solution . The resonance scattering light intensity at the maximum RLS peak of 569.5 nm was linear to the concentration of tinidazole in the range of 10.0–30.0 gm with a detection limit of 5.0 gm. Good results were also obtained with the recovery range of 95.13–106.76%. The method was applied to determine tinidazole in injections and tablets, showing high sensitivity and accuracy compared with the high performance liquid chromatography method (HPLC) according to Chinese Pharmacopoeia.
- S. C. Sweetman, Martindale: The Complete Drug Reference, Pharmaceutical Press, London, UK, 2002.
- H. Salomies, “Structure elucidation of the photolysis and hydrolysis products of tinidazole,” Acta Pharmaceutica Nordica, vol. 3, no. 4, pp. 211–214, 1991.
- R. F. Pasternack, C. Bustamante, P. J. Collings, A. Giannetto, and E. J. Gibbs, “Porphyrin assemblies on DNA as studied by a resonance light-scattering technique,” Journal of the American Chemical Society, vol. 115, no. 13, pp. 5393–5399, 1993.
- R. F. Pasternack and P. J. Collings, “Resonance light scattering: a new technique for studying chromophore aggregation,” Science, vol. 269, no. 5226, pp. 935–939, 1995.
- P. J. Collings, E. J. Gibbs, and T. E. Starr et al., “Resonance light scattering and its application in determining the size, shape, and aggregation number for supramolecular assemblies of chromophores,” Journal of Physical Chemistry B, vol. 103, no. 40, pp. 8474–8481, 1999.
- Z. De Liu, C. Z. Huang, Y. F. Li, and Y. F. Long, “Enhanced plasmon resonance light scattering signals of colloidal gold resulted from its interactions with organic small molecules using captopril as an example,” Analytica Chimica Acta, vol. 577, no. 2, pp. 244–249, 2006.
- Z. Chen, J. Liu, Y. Han, and L. Zhu, “A novel histidine assay using tetraphenylporphyrin manganese (III) chloride as a molecular recognition probe by resonance light scattering technique,” Analytica Chimica Acta, vol. 570, no. 1, pp. 109–115, 2006.
- C. Z. Huang, W. Lu, Y. F. Li, and Y. M. Huang, “On the factors affecting the enhanced resonance light scattering signals of the interactions between proteins and multiply negatively charged chromophores using water blue as an example,” Analytica Chimica Acta, vol. 556, no. 2, pp. 469–475, 2006.
- Y. J. Long, Y. F. Li, and C. Z. Huang, “A wide dynamic range detection of biopolymer medicines with resonance light scattering and absorption ratiometry,” Analytica Chimica Acta, vol. 552, no. 1-2, pp. 175–181, 2005.
- Z. Chen, W. Ding, F. L. Ren, J. Liu, and Y. Liang, “A simple and sensitive assay of nucleic acids based on the enhanced resonance light scattering of zwitterionics,” Analytica Chimica Acta, vol. 550, no. 1-2, pp. 204–209, 2005.
- C. Z. Huang and Y. F. Li, “Resonance light scattering technique used for biochemical and pharmaceutical analysis,” Analytica Chimica Acta, vol. 500, no. 1-2, pp. 105–117, 2003.
- J. B. Xiao, C. S. Yang, F. L. Ren, X. Y. Jiang, and M. Xu, “Rapid determination of ciprofloxacin lactate in drugs by the Rayleigh light scattering technique,” Measurement Science and Technology, vol. 18, no. 3, pp. 859–866, 2007.
- Q. Wei, H. Zhang, B. Du, Y. Li, and X. Zhang, “Sensitive determination of DNA by resonance light scattering with pentamethoxyl red,” Microchimica Acta, vol. 151, no. 1-2, pp. 59–65, 2005.
- Z. Chen, W. Ding, Y. Liang, F. L. Ren, Y. Han, and J. Liu, “Determination of nucleic acids based on their resonance light scattering enhancement effect on metalloporphyrin derivatives,” Microchimica Acta, vol. 150, no. 1, pp. 35–42, 2005.
- Z. Chen, T. Zhang, F. L. Ren, and W. Ding, “Determination of proteins at nanogram levels based on their resonance light scattering decrease effect on the dibromo-o-nitrophenylfluorone-sodium lauroyl glutamate system,” Microchimica Acta, vol. 153, no. 1-2, pp. 65–71, 2006.
- Y. Zhou, S. She, L. Zhang, and Q. Lu, “Determination of proteins at nanogram levels using the resonance light scattering technique with a novel PVAK nanoparticle,” Microchimica Acta, vol. 149, no. 1-2, pp. 151–156, 2005.
- J. B. Xiao, J. W. Chen, F. L. Ren, Y. Y. Chen, and M. Xu, “Highly sensitive detection of trace potassium ion in serum using resonance light scattering technique with sodium tetraphenylboron,” to appear in Microchimica Acta.
- J. B. Xiao, J. W. Chen, F. L. Ren, C. S. Yang, and M. Xu, “Use of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide for rapid detection of methicillin-resistant Staphylococcus aureus by resonance light scattering,” Analytica Chimica Acta, vol. 589, no. 2, pp. 186–191, 2007.
- K. Rajnarayana, M. R. Chaluvadi, V. R. Alapati, S. R. Mada, G. Jayasagar, and D. R. Krishna, “Validated HPLC method for the determination of tinidazole in human serum and its application in a clinical pharmacokinetic study,” Pharmazie, vol. 57, no. 8, pp. 535–537, 2002.
- M. Bakshi and S. Singh, “HPLC and LC-MS studies on stress degradation behaviour of tinidazole and development of a validated specific stability-indicating HPLC assay method,” Journal of Pharmaceutical and Biomedical Analysis, vol. 34, no. 1, pp. 11–18, 2004.
- L. Zhang, Z. Zhang, and K. Wu, “In vivo and real time determination of ornidazole and tinidazole and pharmacokinetic study by capillary electrophoresis with microdialysis,” Journal of Pharmaceutical and Biomedical Analysis, vol. 41, no. 4, pp. 1453–1457, 2006.
- P. Nagaraja, K. R. Sunitha, R. A. Vasantha, and H. S. Yathirajan, “Spectrophotometric determination of metronidazole and tinidazole in pharmaceutical preparations,” Journal of Pharmaceutical and Biomedical Analysis, vol. 28, no. 3-4, pp. 527–535, 2002.
- C. Yang, “Voltammetric determination of tinidazole using a glassy carbon electrode modified with single-wall carbon nanotubes,” Analytical Sciences, vol. 20, no. 5, pp. 821–824, 2004.
- A. Z. Abu Zuhri, S. Al-Khalil, R. M. Shubietah, and I. El-Hroub, “Electrochemical study on the determination of tinidazole in tablets,” Journal of Pharmaceutical and Biomedical Analysis, vol. 21, no. 4, pp. 881–886, 1999.
- S. A. Özkan, Y. Özkan, and Z. Şentürk, “Electrochemical reduction of metronidazole at activated glassy carbon electrode and its determination in pharmaceutical dosage forms,” Journal of Pharmaceutical and Biomedical Analysis, vol. 17, no. 2, pp. 299–305, 1998.
- S. K. Sindhwani and R. P. Singh, “Spectrophotometric determination of osmium using acenaphthenequinonemonoxime,” Microchemical Journal, vol. 18, no. 6, pp. 627–635, 1973.
- S. Z. Zhang, F. L. Zhao, K. A. Li, and S. Y. Tong, “A study on the interaction between concanavalin A and glycogen by light scattering technique and its analytical application,” Talanta, vol. 54, no. 2, pp. 333–342, 2001.
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