Journal of Analytical Methods in Chemistry

Journal of Analytical Methods in Chemistry / 2007 / Article

Research Article | Open Access

Volume 2007 |Article ID 086857 | https://doi.org/10.1155/2007/86857

Xin Yu Jiang, Xiao Qing Chen, Zheng Dong, Ming Xu, "The Application of Resonance Light Scattering Technique for the Determination of Tinidazole in Drugs", Journal of Analytical Methods in Chemistry, vol. 2007, Article ID 086857, 7 pages, 2007. https://doi.org/10.1155/2007/86857

The Application of Resonance Light Scattering Technique for the Determination of Tinidazole in Drugs

Received13 Jan 2007
Accepted26 Apr 2007
Published14 Jun 2007

Abstract

A resonance light scattering technique to determine tinidazole in drugs was developed by tetraphenylboron sodium (TPB). Tinidazole was found to bind B(C6H5)4 anion and transformed to tinidazole-TPB aggregate which displayed intense resonance scattering light. Effects of factors such as wavelength, acidity, stabilizers, and interferents on the RLS of tinidazole TPB were investigated in detail. The RLS intensity of the tinidazole-TPB suspension was obtained in sulfuric acid solution (pH=1.44). The resonance scattering light intensity at the maximum RLS peak of 569.5 nm was linear to the concentration of tinidazole in the range of 10.0–30.0 μgmL1 with a detection limit of 5.0 μgmL1. Good results were also obtained with the recovery range of 95.13–106.76%. The method was applied to determine tinidazole in injections and tablets, showing high sensitivity and accuracy compared with the high performance liquid chromatography method (HPLC) according to Chinese Pharmacopoeia.

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Copyright © 2007 Xin Yu Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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