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Journal of Automated Methods and Management in Chemistry
Volume 2008 (2008), Article ID 498921, 14 pages
Research Article

Increasing Efficiency and Quality by Consolidation of Clinical Chemistry and Immunochemistry Systems with MODULAR ANALYTICS SWA

1University Department of Laboratory Medicine, Hospital of Desio, Via Benefattori 2, 20033 Desio Milano, Italy
2Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215-5400, USA
3Gemeinschaftspraxis Dr. med. Bernd Schottdorf u.a., 86154 Augsburg, Germany
4Department of Clinical Chemistry, Ziekenhuis Rijnstate Arnhem, 6800 TA Arnhem, The Netherlands
5Department of Clinical Chemistry, Georg-August-University Göttingen, 37075 Göttingen, Germany
6Hospital de la Plana, Vila Real 1254, Castelló, Spain
7Roche Diagnostics GmbH, Sandhofer Street 116, 68305 Mannheim, Germany
8Roche Diagnostics Operations, Inc., 9115 Hague Road, P.O. Box 50416, Indianapolis, IN 46250, USA

Received 25 October 2007; Accepted 19 December 2007

Academic Editor: Peter Stockwell

Copyright © 2008 Paolo Mocarelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


MODULAR ANALYTICS Serum Work Area (in USA Integrated MODULAR ANALYTICS, MODULAR ANALYTICS is a trademark of a member of the Roche Group) represents a further approach to automation in the laboratory medicine. This instrument combines previously introduced modular systems for the clinical chemistry and immunochemistry laboratory and allows customised combinations for various laboratory workloads. Functionality, practicability, and workflow behaviour of MODULAR ANALYTICS Serum Work Area were evaluated in an international multicenter study at six laboratories. Across all experiments, 236000 results from 32400 samples were generated using 93 methods. Simulated routine testing which included provocation incidents and anomalous situations demonstrated good performance and full functionality. Heterogeneous immunoassays, performed on the E-module with the electrochemiluminescence technology, showed reproducibility at the same level of the general chemistry tests, which was well within the clinical demands. Sample carryover cannot occur due to intelligent sample processing. Workflow experiments for the various module combinations, with menus of about 50 assays, yielded mean sample processing times of < 38 minutes for combined clinical chemistry and immunochemistry requests; < 50 minutes including automatically repeated samples. MODULAR ANALYTICS Serum Work Area offered simplified workflow by combining various laboratory segments. It increased efficiency while maintaining or even improving quality of laboratory processes.