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Journal of Automated Methods and Management in Chemistry
Volume 2010 (2010), Article ID 972926, 13 pages
http://dx.doi.org/10.1155/2010/972926
Research Article

New Automated and High-Throughput Quantitative Analysis of Urinary Ketones by Multifiber Exchange-Solid Phase Microextraction Coupled to Fast Gas Chromatography/Negative Chemical-Electron Ionization/Mass Spectrometry

1Occupational Health Division, Department of Public Health, Viale Morgagni 48, University of Florence, 50100 Florence, Italy
2CNR-Istitute of Molecular Science and Technologies, Corso Stati Uniti 4, 35100 Padova, Italy
3Chromline Srl, Via Anita Garibaldi 40, 59100 Prato, Italy
4Organic Chemistry Department/ProtEra Srl (Spin Off of Magnetic Resonance Center), Via Lastruccia 13, University of Florence, Sesto Fiorentino, 50019 Florence, Italy
5Department of Chemical, Environmental and Raw Materials Engineering (DICAMP), Piazzale Europa 1, University of Trieste, 34127 Trieste, Italy

Received 16 December 2009; Accepted 12 April 2010

Academic Editor: Peter B. Stockwell

Copyright © 2010 Marco Pacenti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Perbellini and C. Minoia, “Escrezione dei solventi,” in Monitoraggio Ambientale e Biologico dell'Esposizione Professionale a Xenobiotici: Solventi II, pp. 71–81, Morgan Edizioni Tecniche, Milan, Italy, 2001. View at Google Scholar
  2. T. Kawai, Y. Miyama, S. Horiguchi et al., “Possible metabolic interaction between hexane and other solvents co-exposed at sub-occupational exposure limit levels,” International Archives of Occupational and Environmental Health, vol. 73, no. 7, pp. 449–456, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Carmant, “Assessing ketosis: approaches and pitfalls,” Epilepsia, vol. 49, supplement 8, pp. 20–22, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. M. J. Prieto, D. Marhuenda, J. Roel, and A. Cardona, “Free and total 2,5-hexanedione in biological monitoring of workers exposed to n-hexane in the shoe industry,” Toxicology Letters, vol. 145, no. 3, pp. 249–260, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Vanelli, G. Chiari, and C. Capuano, “Cost effectiveness of the direct measurement of 3-β-hydroxybutyrate in the management of diabetic ketoacidosis in children,” Diabetes Care, vol. 26, no. 3, p. 959, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. J. G. M. van Engelen, S. Kezić, W. de Haan, J. J. G. Opdam, and F. A. de Wolff, “Determination of 2,5-hexanedione, a metabolite of n-hexane, in urine: evaluation and application of three analytical methods,” Journal of Chromatography B, vol. 667, no. 2, pp. 233–240, 1995. View at Publisher · View at Google Scholar · View at Scopus
  7. A. A. Matin, R. Maleki, M. A. Farajzadeh, K. Farhadi, R. Hosseinzadeh, and A. Jouyban, “Headspace SPME-GC method for acetone analysis and its biomedical application,” Chromatographia, vol. 66, no. 5-6, pp. 383–387, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Kobayashi, M. Okada, Y. Yasuda, and S. Kawai, “A gas chromatographic method for the determination of acetone and acetoacetic acid in urine,” Clinica Chimica Acta, vol. 133, no. 2, pp. 223–226, 1983. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Kezić and A. C. Monster, “Determination of 2,5-hexanedione in urine and serum by gas chromatography after derivatization with O-(pentafluorobenzyl)hydroxylamine and solid-phase extraction,” Journal of Chromatography, vol. 563, no. 1, pp. 199–204, 1991. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Ghittori, M. Imbriani, G. Pezzagno, and E. Capodaglio, “The urinary concentration of solvents as a biological indicator of exposure: proposal for the biological equivalent exposure limit for nine solvents,” American Industrial Hygiene Association Journal, vol. 48, no. 9, pp. 786–790, 1987. View at Google Scholar · View at Scopus
  11. S. Strassnig, M. Gfrerer, and E. P. Lankmayr, “Microwave-assisted derivatization of 2,5-hexanedione in urine: evaluation using GC-MS and GC-ECD,” Journal of Chromatography B, vol. 813, no. 1-2, pp. 151–158, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Yamato, K. Kobayashi, K. Ebara, K. Shimada, and S. Ohta, “High performance liquid chromatographic determination of acetoacetate by post-column derivatization with p-nitrobenzene diazonium fluoroborate,” Biological and Pharmaceutical Bulletin, vol. 26, no. 4, pp. 397–400, 2003. View at Google Scholar · View at Scopus
  13. A. Pysanenko, T. Wang, P. Španěl, and D. Smith, “Acetone, butanone, pentanone, hexaeone and heptanone in the headspace of aqueous solution and urine studied by selected ion flow tube mass spectrometry,” Rapid Communications in Mass Spectrometry, vol. 23, no. 8, pp. 1097–1104, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. S. W. Smith, A. F. Manini, T. Szekely, and R. S. Hoffman, “Bedside detection of urine β-hydroxybutyrate in diagnosing metabolic acidosis,” Academic Emergency Medicine, vol. 15, no. 8, pp. 751–756, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Q. Tranchida, M. L. Presti, R. Costa, P. Dugo, G. Dugo, and L. Mondello, “High-throughput analysis of bergamot essential oil by fast solid-phase microextraction-capillary gas chromatography-flame ionization detection,” Journal of Chromatography A, vol. 1103, no. 1, pp. 162–165, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Handley and C. M. Harris, “Great ideas of a decade,” Analytical Chemistry, vol. 73, no. 23, pp. 660–666, 2001. View at Google Scholar · View at Scopus
  17. B. E. Poling, J. M. Prausnitz, and J. P. O'Connell, The Properties of Gases and Liquids, McGraw–Hill, New York, NY, USA, 2001.
  18. L. H. Nelken, “Densities of vapors, liquids and solids,” in Handbook of Chemical Property Estimation Methods, W. J. Lyman, W. F. Reehl, and D. H. Rosenblatt, Eds., chapter 19, American Mathematical Society, Providence, RI, USA, 1990. View at Google Scholar
  19. C. F. Grain, “Vapor pressure,” in Handbook of Chemical Property Estimation methods, W. J. Lyman, W. F. Reehl, and D. H. Rosenblatt, Eds., chapter 14, American Mathematical Society, Providence, RI, USA, 1990. View at Google Scholar
  20. E. J. Baum, Chemical Property Estimation, Theory and Application, CRC Press, Boca Raton, Fla, USA, 1998.
  21. Aa. Fredenslund and J. M. Sørensen, “Group contribution estimation methods,” in Models for Thermodynamic and Phase Equilibria Calculations, S. S. Sandler, Ed., chapter 4, Marcel Dekker, New York, NY, USA, 1993. View at Google Scholar
  22. H. Destaillats and M. J. Charles, “Henry's law constants of carbonyl-pentafluorobenzyl hydroxylamine (PFBHA) derivatives in aqueous solution,” Journal of Chemical and Engineering Data, vol. 47, no. 6, pp. 1481–1487, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. J. C. Miller and J. N. Miller, Statistics for Analytical Chemistry, vol. 4, Ellis Horwood, New York, NY, USA, 1984.
  24. X. Duan, D. Zhong, and X. Chen, “Derivatization of β-dicarbonyl compound with 2,4- dinitrophenylhydrazine to enhance mass spectrometric detection: application in quantitative analysis of houttuynin in human plasma,” Journal of Mass Spectrometry, vol. 43, no. 6, pp. 814–824, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. C. N. Konidari, C. D. Stalikas, and M. I. Karayannis, “Gas chromatographic method for the sensitive determination of 2,5-hexanedione using electron capture and mass-selective detection,” Analytica Chimica Acta, vol. 442, no. 2, pp. 231–239, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. E. E. Stashenko, M. A. Puertas, W. Salgar, W. Delgado, and J. R. Martínez, “Solid-phase microextraction with on-fibre derivatisation applied to the analysis of volatile carbonyl compounds,” Journal of Chromatography A, vol. 886, no. 1-2, pp. 175–181, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Weisser and G. Spiteller, “Increase of aldehydic compounds derived from plasmalogens in the brain of aged cattle,” Chemistry and Physics of Lipids, vol. 82, no. 2, pp. 173–178, 1996. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Pacenti, S. Dugheri, R. Gagliano-Candela et al., “Analysis of 2-Chloroacetophenone in air by multi-fiber solid-phase microextraction and fast gas chromatography-mass spectrometry,” Acta Chromatographica, vol. 21, no. 3, pp. 379–397, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Pieraccini, G. Bartolucci, M. Pacenti, S. Dugheri, P. Boccalon, and L. Focardi, “Gas chromatographic determination of glutaraldehyde in the workplace atmosphere after derivatization with O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine on a solid-phase microextraction fibre,” Journal of Chromatography A, vol. 955, no. 1, pp. 117–124, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. Q. Wang, J. O'Reilly, and J. Pawliszyn, “Determination of low-molecular mass aldehydes by automated headspace solid-phase microextraction with in-fibre derivatisation,” Journal of Chromatography A, vol. 1071, no. 1-2, pp. 147–154, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. J. P. Vidal, S. Estreguil, and R. Cantagrel, “Quantitative analysis of cognac carbonyl compounds at the PPB level by GC-MS of their 0-(pentafluorobenzyl amine) derivatives,” Chromatographia, vol. 36, pp. 183–186, 1993. View at Google Scholar · View at Scopus
  32. J. Larreta, A. Usobiaga, N. Etxebarria, G. Arana, and O. Zuloaga, “Optimisation of the on-fibre derivatisation of volatile fatty acids in the simultaneous determination together with phenols and indoles in cow slurries,” Analytical and Bioanalytical Chemistry, vol. 389, no. 5, pp. 1603–1609, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Pacenti, S. Dugheri, F. Villanelli et al., “Determination of organic acids in urine by solid-phase microextraction and gas chromatography-ion trap tandem mass spectrometry previous ‘in sample’ derivatization with trimethyloxonium tetrafluoroborate,” Biomedical Chromatography, vol. 22, no. 10, pp. 1155–1163, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. P. L. Neitzel, W. Walther, and W. Nestler, “In-situ methylation of strongly polar organic acids in natural waters supported by ion-pairing agents for headspace GC-MSD analysis,” Fresenius' Journal of Analytical Chemistry, vol. 361, no. 3, pp. 318–323, 1998. View at Google Scholar · View at Scopus
  35. N. M. Moreau, S. M. Goupry, J. P. Antignac et al., “Simultaneous measurement of plasma concentrations and 13C-enrichment of short-chain fatty acids, lactic acid and ketone bodies by gas chromatography coupled to mass spectrometry,” Journal of Chromatography B, vol. 784, no. 2, pp. 395–403, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Gmeiner, P. Gärtner, C. Krassnig, and H. Tausch, “Identification of various urinary metabolites of fluorene using derivatization solid-phase microextraction,” Journal of Chromatography B, vol. 766, no. 2, pp. 209–218, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. D. Louch, S. Motlagh, and J. Pawliszyn, “Dynamics of organic compound extraction from water using liquid-coated fused silica fibers,” Analytical Chemistry, vol. 64, no. 10, pp. 1187–1199, 1992. View at Google Scholar · View at Scopus
  38. P. Canosa, I. Rodriguez, E. Rubì, and R. Cela, “Optimization of solid-phase microextraction conditions for the determination of triclosan and possible related compounds in water samples,” Journal of Chromatography A, vol. 1072, no. 1, pp. 107–115, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. H. M. Liebich and E. Gesele, “Profiling of organic acids by capillary gas chromatography-mass spectrometry after direct methylation in urine using trimethyloxonium tetrafluoroborate,” Journal of Chromatography A, vol. 843, no. 1-2, pp. 237–245, 1999. View at Publisher · View at Google Scholar · View at Scopus
  40. Z. Zhang and J. Pawliszyn, “Headspace solid-phase microextraction,” Analytical Chemistry, vol. 65, no. 14, pp. 1843–1852, 1993. View at Google Scholar · View at Scopus
  41. K. Kolář, M. Ciganek, and J. Malecha, “Air/polymer distribution coefficients for polycyclic aromatic hydrocarbons by solid-phase microextraction sampling,” Journal of Chromatography A, vol. 1029, no. 1-2, pp. 263–266, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. F. F. Hsu, S. L. Hazen, D. Giblin, J. Turk, J. W. Heinecke, and M. L. Gross, “Mass spectrometric analysis of pentafluorobenzyl oxime derivatives of reactive biological aldehydes,” International Journal of Mass Spectrometry, vol. 187, pp. 795–812, 1999. View at Google Scholar