Capture-SELEX: Selection of DNA Aptamers for Aminoglycoside Antibiotics

Table 1

Characteristics of the four pharmaceuticals used in the Capture-SELEX process as target mixture.

Pharmaceutical	Kanamycin A disulfate salt dihydrate	Sulfacarbamide	Sulfamethoxazole	Sotalol hydrochloride
CAS number	64013-70-3	547-44-4	723-46-6	959-24-0
Chemical structure
Drug family	Aminoglycoside antibiotics	Sulfonamide antibiotics	Sulfonamide antibiotics	β-adrenergic receptor blocker
Molecular mass [g/moL]	680.66	215.23	253.28	272.36
Solubility	Water: 50 g/L^1	Water: 1.2 g/L at 37°C^2	Water: 0.61 g/L at 37°C^2	Water: 19.60–20.40 g/L^3

Data sources: ¹[16], ²[17], ³[18].