High-Performance Liquid Chromatography Assay for Moxifloxacin in Brain Tissue and Plasma: Validation in a Pharmacokinetic Study in a Murine Model of Cerebral Listeriosis

Table 2

Plasma and cerebral pharmacokinetic parameters after intraperitoneal administration of moxifloxacin (50 mg/kg) in infected and control mice (𝑛=6).

	𝑇max (h)	𝐶max	𝑇1/2 (h)	Cl (L/h)	Vd (L/kg)	AUC0-24h
Plasma		(mg/L)				(mg⋅h/L)
Infected	0.75	17.3 ± 6.6	1.9	0.02	3.5	27.1
Control	1	6.7 ± 1.2	1.1	0.08	6.5	9.5
Brain tissue		(μg/g of brain)				(μg⋅h/g of brain)
Infected	0.75	2.0 ± 0.2	21.7			3.3
Control	1	0.8 ± 0.3	10.7			1.0