Acylation of Chiral Alcohols: A Simple Procedure for Chiral GC Analysis

Table 1

Influence of solvent presence, reaction time, and molar ratio 2-heptanol : acetic acid in the 1-methylhexyl acetate yields.

Entry	Solvent	Time (h)	Molar ratio (2-heptanol : acetic acid)	% 1-methylhexyl acetate	SD	Tukey-Kramer*
1	No solvent	24	1 : 2	90.63	0.51	A
2		24	1 : 6	90.03	2.12	A B
3		24	1 : 10	84.00	1.79	B
4		48	1 : 2	91.76	2.84	A
5		48	1 : 6	93.74	2.93	A
6		48	1 : 10	93.11	1.26	A
7	tert-Butanol	24	1 : 2	16.63	1.05	C
8		24	1 : 6	34.67	0.04	D
9		24	1 : 10	56.20	0.01	E
10		48	1 : 2	81.72	1.17	B
11		48	1 : 6	88.00	0.09	A B
12		48	1 : 10	82.11	3.22	B

*Tukey-Kramer pairwise differences adjustment method, 𝑛=3.