Research Article
Validated Reverse-Phase High-Performance Liquid Chromatography for Quantification of Furosemide in Tablets and Nanoparticles
Table 1
Experimental design matrix for the robustness study and response values (
).
| Pattern | Acetonitrile percent in water (%) v/v | Wavelength (nm) | pH | Flow rate (mL·min−1) | | | | |
| | 32 | 228 | 3.7 | 1.1 | | 32 | 232 | 3.7 | 0.9 | | 28 | 232 | 3.9 | 0.9 | | 32 | 232 | 3.9 | 1.1 | | 28 | 232 | 3.7 | 1.1 | | 28 | 228 | 3.7 | 0.9 | | 28 | 228 | 3.9 | 1.1 | | 32 | 228 | 3.9 | 0.9 | Low level | 28 | 228 | 3.7 | 0.9 | High level | 32 | 232 | 3.9 | 1.1 |
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