Journal of Analytical Methods in Chemistry / 2013 / Article / Tab 5

Research Article

Dual Wavelength RP-HPLC Method for Simultaneous Determination of Two Antispasmodic Drugs: An Application in Pharmaceutical and Human Serum

Table 5

Summary of forced degradation results.

Stress conditionsTime (h)Assay of active substance (%)Increase due to oxidation (%)
PG (100 µg/mL)TMP (0.1 µg/mL)PG (100 µg/mL)TMP (0.1 µg/mL)

Acid hydrolysis
(0.1 M HCl)
192.8896.467.123.54
Base hydrolysis
(0.5 M NaOH)
1129.17101.0929.171.09
Oxidation
(30% H2O2)
1623.16103.14523.163.14
Thermal (60°C)1106.53105.946.535.94

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