Validation and Uncertainty Estimation of an Ecofriendly and Stability-Indicating HPLC Method for Determination of Diltiazem in Pharmaceutical Preparations

Table 1

Summary of stress degradation studies of diltiazem.

Stress condition/media/duration	Recovered diltiazem (%); mean (RSD, %)	No. of observed impurities
Photolytic/H2O/254 nm/4 h	48.86 (1.48)	1
Acidic/1.0 N HCl/70°C/12 h	16.67 (1.95)	1
Neutral/H2O/70°C/12 h	84.57 (0.86)	1
Oxidative/3.0% H2O2/4 h	89.01 (1.74)	1
Basic/1.0 N NaOH/70°C/12 h	10.47 (2.10)	2