Simultaneous Determination of Volatile Constituents from Acorus tatarinowii Schott in Rat Plasma by Gas Chromatography-Mass Spectrometry with Selective Ion Monitoring and Application in Pharmacokinetic Study

Table 4

Pharmacokinetic parameters of analytes in rats (𝑛=6).

Analytes	𝑇1/2𝛼  (min)	𝑇1/2𝛽  (min)	𝑇1/2  (min)	AUC(0∼𝑡)  (mg/L·min)	AUC(0∼∞)  (mg/L·min)	CL (mL/min/kg)	Vd (L/kg)	𝑇max  (min)	𝐶max  (𝜇g/mL)
Methyl Eugenol			67.66 ± 3.32	2.13 ± 0.27	2.49 ± 0.25	0.40 ± 0.04	39.35 ± 4.08	10.00 ± 0.00	0.021 ± 0.001
𝛽-Asarone	54.39 ± 29.46	69.30 ± 0.21		368.43 ± 40.05	407.52 ± 55.78	0.38 ± 0.05	149.87 ± 90.78	13.75 ± 11.09	2.47 ± 0.58
𝛼-Asarone	58.92 ± 20.80	69.28 ± 6.12		47.51 ± 28.49	56.67 ± 35.91	0.60 ± 0.44	22.93 ± 16.11	11.25 ± 6.29	0.53 ± 0.24