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Journal of Analytical Methods in Chemistry
Volume 2013, Article ID 976034, 8 pages
http://dx.doi.org/10.1155/2013/976034
Research Article

Validation and Application of a New Reversed Phase HPLC Method for In Vitro Dissolution Studies of Rabeprazole Sodium in Delayed-Release Tablets

Quality Assurance Department, ACI Ltd., Narayanganj 1400, Bangladesh

Received 21 May 2013; Revised 18 July 2013; Accepted 19 July 2013

Academic Editor: Josep Esteve-Romero

Copyright © 2013 Md. Saddam Nawaz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

According to ICH (International Conference on Harmonization) Q2 (R1) and the USP (United States Pharmacopeia), the linearity of an analytical procedure is its ability (within a given range) to obtain test results which are directly proportional to the concentration (amount) of analyte in the sample and normally calculated by using an appropriate least-squares regression program. Typically, a square of the correlation coefficient (R2 ≥ 0.98) demonstrates linearity. In this proposed RP-HPLC method the linear regression equation for RPS was found, y = 20,235x – 432, (R2 = 0.9999) by plotting peak area (y) versus the concentration (x). The results show that an excellent correlation exists between peak areas and concentrations of the drug.

  1. Supplementary Material