Validation and Application of a New Reversed Phase HPLC Method for In Vitro Dissolution Studies of Rabeprazole Sodium in Delayed-Release Tablets

Table 6

Robustness of the method.

Parameters	Variance	Amount added (μg/mL)	Retention time (min)	Mean area of peak ± %RSD, 𝑛 = 3
				Standard	Sample
Flow rate	0.9 mL/min	10	2.8	219467 ± 0.3	225203 ± 0.4
	1.1 mL/min	10	2.2	184626 ± 0.3	188516 ± 0.3
Organic (%) in mobile phase	59	10	2.7	207066 ± 0.5	206049 ± 0.3
	61	10	2.5	203858 ± 0.3	203051 ± 0.4
Detector wavelength	278 nm	10	2.7	199421 ± 0.2	198228 ± 0.6
	282 nm	10	2.7	213519 ± 0.4	211768 ± 0.7