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Journal of Analytical Methods in Chemistry
Volume 2014, Article ID 424790, 9 pages
http://dx.doi.org/10.1155/2014/424790
Research Article

Ultrasensitive Detection of Ferulic Acid Using Poly(diallyldimethylammonium chloride) Functionalized Graphene-Based Electrochemical Sensor

1School of Pharmacy, Lanzhou University, Lanzhou 730000, China
2Gansu College of Traditional Chinese Medicine, Lanzhou 730000, China
3Department of Chemistry, Lanzhou University, Lanzhou 730000, China

Received 5 March 2014; Accepted 14 April 2014; Published 12 May 2014

Academic Editor: Jun-Jie Zhu

Copyright © 2014 Lin-jie Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The electrochemical redox of ferulic acid (FA) was investigated systematically by cyclic voltammetry (CV) with a poly(diallyldimethylammonium chloride) functionalized graphene-modified glassy carbon electrode (PDDA-G/GCE) as a working electrode. A simple and sensitive differential pulse voltammetry (DPV) technique was proposed for the direct quantitative determination of FA in Angelica sinensis and spiked human urine samples for the first time. The dependence of the intensities of currents and potentials on nature of the supporting electrolyte, pH, scan rate, and concentration was investigated. Under optimal conditions, the proposed sensor exhibited excellent electrochemical sensitivity to FA, and the oxidation peak current was proportional to FA concentration in the range of  M  M, with a relatively low detection limit of  M. This fabricated sensor also displayed acceptable reproducibility, long-term stability, and high selectivity with negligible interferences from common interfering species. Besides, it was applied to detect FA in Angelica sinensis and biological samples with satisfactory results, making it a potential alternative tool for the quantitative detection of FA in pharmaceutical analysis.