Research Article
Quantification of Neurotransmitters in Mouse Brain Tissue by Using Liquid Chromatography Coupled Electrospray Tandem Mass Spectrometry
Table 4
The levels of tetrahydrobiopterin (BH4) and neurotransmitters in mouse brain regions.
| Brain regions | BH4 (ng/g) | DA (ng/g) | 5-HT (ng/g) | NE (ng/g) | EP (ng/g) | Glu (g/g) | GABA (g/g) |
| Striatum | 164.0 ± 21.79 | 3463 ± 200.9 | 207.7 ± 17.81 | 457.6 ± 73.59 | 28.55 ± 3.06 | 1037 ± 86.57 | 397.4 ± 7.466 | Midbrain | 129.2 ± 9.86 | 59.8 ± 6.19 | 486.7 ± 50.10 | 802.5 ± 60.52 | 73.5 ± 9.54 | 670.2 ± 98.11 | 682.2 ± 34.66 | Hippocampus | 21.5 ± 1.40 | ND | 98.1 ± 13.64 | 3170 ± 669.1 | 281.3 ± 33.37 | 3507 ± 1431 | 721.0 ± 56.15 | Olfactory bulb | 577.2 ± 59.79 | 40.6 ± 7.34 | 84.93 ± 9.88 | 734.4 ± 95.53 | 59.7 ± 14.59 | 597.8 ± 90.36 | 772.1 ± 92.21 | Frontal cortex | 212.5 ± 52.27 | ND | 81.83 ± 6.25 | 320.1 ± 55.30 | 44.9 ± 6.85 | 1090 ± 108.1 | 430.8 ± 17.47 | Hypothalamus | 84.8 ± 14.17 | 111.9 ± 26.17 | 282.4 ± 28.42 | 2627 ± 135.4 | 188.0 ± 27.68 | 811.8 ± 136.8 | 829.7 ± 65.56 | Cerebellum | 293.4 ± 69.74 | ND | 29.17 ± 4.07 | 584.5 ± 79.12 | ND | 791.9 ± 62.29 | 389.9 ± 14.88 | Brainstem | 60.9 ± 9.02 | ND | 452.5 ± 50.03 | 1123 ± 82.11 | 78.4 ± 9.71 | 622.5 ± 37.00 | 348.9 ± 18.10 | Pituitary gland | 92.2 ± 19.29 | 48.9 ± 18.9 | ND | 2539 ± 358.5 | 35.5 ± 9.00 | 536.6 ± 70.25 | 22.03 ± 1.733 |
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Unit: Mean ± SEM ug/tissue weight (g).
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