Automated System for Kinetic Analysis of Particle Size Distributions for Pharmaceutically Relevant Systems

Figure 4

The effects of calcium concentration ranging from 0.9 mmol/L to 12.7 mmol/L on calcium phosphate particle formation for a nutritional admixture stored at 37°C are monitored through the appearance of particles ≥10 microns in size. The time-dependent evolution of particle counts/mL shows shorter induction times and greater particle concentrations with increasing calcium concentrations greater than 7.3 mmol/L.