Quantitative Determination of Lercanidipine Enantiomers in Commercial Formulations by Capillary Electrophoresis

Figure 3

Effect of (a) TM-β-CD concentration (mmol/L); (b) buffer concentration (mmol/L); (c) temperature (°C) and (d) voltage (kV) on the migration time (min) of LER enantiomers. Experimental conditions: fused-silica uncoated capillary 50 μm id, 60.2 cm in total length and 50.0 cm in effective length, sodium acetate buffer pH 4.0, and 15°C, 25 kV, 237 nm, and injection: 10 seconds (at a pressure of 0.5 psi). Other conditions were changed according to each experiment.

(a)

(b)

(c)

(d)