Determination of Matrine in Rat Plasma after Oral Administration of Novel Korean Herbal Medicine KIOM-MA128 and Application of PK

Table 2

Stability test results of matrine in rat plasma.

Stability test	Storage condition	10 ng/mL	1000 ng/mL
		%stability	%stability
Short-term in plasma	Room temperature for 6 hr	108.36	90.69
Long-term in plasma	−70°C for 14 days	98.51	101.82
Freeze–thaw cycle in plasma	−70°C after the third cycle	92.06	90.86
Process (extracted sample)	4°C, for 24 hr	102.71	105.92
Stock solution	−20°C, for 14 days	98.51	107.33