Development of Sensitive and Specific Analysis of Vildagliptin in Pharmaceutical Formulation by Gas Chromatography-Mass Spectrometry

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left">Selected variables</td><td align="center">Low level (−)</td><td align="center">High level (+)</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">Analyst  </td><td align="center">Analyst I</td><td align="center">Analyst II</td></tr><tr><td align="left">Brand of MSTFA</td><td align="center">MSTFA I</td><td align="center">MSTFA II</td></tr><tr><td align="left">Derivatization time (min) (±5)</td><td align="center">25</td><td align="center">35</td></tr><tr><td align="left">Derivatization temperature (°C) (±5)</td><td align="center">55</td><td align="center">65</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Selected method parameters and their levels for Plackett-Burman experimental design.

Journal of Analytical Methods in Chemistry

tab1

Table 1

Table 1: Development of Sensitive and Specific Analysis of Vildagliptin in Pharmaceutical Formulation by Gas Chromatography-Mass Spectrometry 