Stability-Indicating RP-HPLC Method for Simultaneous Estimation of Enrofloxacin and Its Degradation Products in Tablet Dosage Forms

Table 6

Degradation data of EFX tablets.

Degradation conditions	%Decarboxylated; impurity	%ED analogue	%Ciprobase impurity	%Chloro impurity	%FQ acid	%Total unknown; impurities	%Total; impurities
Acid treatment; (5 N HCl, 70°C, 1 hr)	—	0.02	0.05	0.12	0.03	0.10	0.31
Base treatment; (5 N NaOH, 70°C, 1 hr)	0.04	—	0.05	0.12	0.02	0.14	0.37
Peroxide treatment; (30% H2O2, 70°C, 1 hr)	0.04	—	0.06	0.12	0.02	0.62	0.86
Thermal-80°C, 5 days	—	—	0.05	0.12	0.02	0.11	0.29
Humidity-90% RH,; 25°C, 7 days	0.01	—	0.06	0.12	0.02	0.13	0.33
Photolytic-1.2 m lux hr, 200 Watt hr/m^2	—	—	0.06	0.13	0.01	0.17	0.38