Stability-Indicating RP-HPLC Method for Simultaneous Estimation of Enrofloxacin and Its Degradation Products in Tablet Dosage Forms

Table 9

Robustness results (control sample and column temperature variations).

Name of the impurity	Control sample		Using other batch columns		Low column temperature 30°C		High column temperature 40°C
	RRT	Resolution	RRT	Resolution	RRT	Resolution	RRT	Resolution
%Decarboxylated impurity	0.57	—	0.56	—	0.56	—	0.56	—
%Desfluoro impurity	0.79	15.25	0.79	14.31	0.79	15.83	0.77	13.82
%ED impurity	0.85	3.92	0.85	3.58	0.86	4.17	0.83	3.12
%Cipro base impurity	0.96	6.17	0.96	5.57	0.96	5.62	0.94	6.13
Enrofloxacin	1.00	2.16	1.00	1.85	1.00	1.81	1.00	2.48
%Chloro impurity	1.32	16.28	1.32	13.78	1.31	15.69	1.33	15.71
%FQ acid impurity	1.81	36.71	1.84	36.64	1.71	28.86	1.93	39.78