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Journal of Analytical Methods in Chemistry
Volume 2015, Article ID 835986, 5 pages
http://dx.doi.org/10.1155/2015/835986
Research Article

Stability-Indicating HPLC Assay for Determination of Idebenone in Pharmaceutical Forms

Service Pharmacie, Hôpital Jean-Verdier, Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires de Paris-Seine-Saint-Denis, avenue du 14 Juillet, 93140 Bondy, France

Received 4 September 2015; Accepted 7 October 2015

Academic Editor: Vito Verardo

Copyright © 2015 Sonoube Kombath et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. D. Esposti, A. Ngo, A. Ghelli et al., “The interaction of Q analogs, particularly hydroxydecyl benzoquinone (idebenone), with the respiratory complexes of heart mitochondria,” Archives of Biochemistry and Biophysics, vol. 330, no. 2, pp. 395–400, 1996. View at Publisher · View at Google Scholar · View at Scopus
  2. V. Geromel, N. Darin, D. Chrétien et al., “Coenzyme Q10 and idebenone in the therapy of respiratory chain diseases: rationale and comparative benefits,” Molecular Genetics and Metabolism, vol. 77, no. 1-2, pp. 21–30, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Nagaoka, M. Suno, M. Shibota, and M. Kakihana, “Effects of idebenone on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia,” Archives of Gerontology and Geriatrics, vol. 8, no. 3, pp. 193–202, 1989. View at Publisher · View at Google Scholar · View at Scopus
  4. I. Zs.-Nagy, “Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review,” Archives of Gerontology and Geriatrics, vol. 11, no. 3, pp. 177–186, 1990. View at Publisher · View at Google Scholar · View at Scopus
  5. E. Mercuri and F. Muntoni, “Efficacy of idebenone in Duchenne muscular dystrophy,” The Lancet, vol. 385, no. 9979, pp. 1704–1706, 2015. View at Publisher · View at Google Scholar
  6. T. Klopstock, G. Metz, P. Yu-Wai-Man et al., “Persistence of the treatment effect of idebenone in Leber's hereditary optic neuropathy,” Brain, vol. 136, no. 2, article e230, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. M. H. Parkinson, J. B. Schulz, and P. Giunti, “Co-enzyme Q10 and idebenone use in Friedreich's ataxia,” Journal of Neurochemistry, vol. 126, supplement 1, pp. 125–141, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. J. K. Lang, K. Gohil, and L. Packer, “Simultaneous determination of tocopherols, ubiquinols, and ubiquinones in blood, plasma, tissue homogenates, and subcellular fractions,” Analytical Biochemistry, vol. 157, no. 1, pp. 106–116, 1986. View at Publisher · View at Google Scholar · View at Scopus
  9. J. K. Lang and L. Packer, “Quantitative determination of vitamin E and oxidized and reduced coenzyme Q by high-performance liquid chromatography with in-line ultraviolet and electrochemical detection,” Journal of Chromatography A, vol. 385, pp. 109–117, 1987. View at Publisher · View at Google Scholar · View at Scopus
  10. ICH, “Q2(R1) validation of analytical procedures: text and methodology,” in Proceedings of the International Conference of Harmonization (ICH '05), 2005, http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q2_R1/Step4/Q2_R1__Guideline.pdf.