Research Article
Stability-Indicating HPLC Assay for Determination of Idebenone in Pharmaceutical Forms
Table 5
Forced degradation study.
| | Stress conditions | % remaining | % degradation | Retention time of degraded products |
| | Acidic stress (1N HCl, 50°C, 1 h) | 51.8 | 48.2 | — | | Alkaline stress (1N NaOH, 50°C, 1 h) | 16.6 | 83.4 | — | | Oxidative stress (3%, 50°C, 48 h) | 84.6 | 15.4 | — | | Thermal stress (50°C, 8 days) | 99.3 | 0.7 | — | | Direct sunlight (8 days) | 95.8 | 4.2 | — | | Ambient temperature (15 days) | 92.0 | 8.0 | — |
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No peak detected.
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