Development and Validation of an HPLC Method for Simultaneous Quantification of Clopidogrel Bisulfate, Its Carboxylic Acid Metabolite, and Atorvastatin in Human Plasma: Application to a Pharmacokinetic Study

Table 6

Results of degradation studies on clopidogrel bisulfate and atorvastatin calcium.

Condition	Time (h)	Temperature (°C)	CLP (recovery %)	ATV (recovery %)	for CLP degraded products	for ATV degraded products
1 M HCl	3	60	62	89	= 8.39; = 9.75	—
1 M NaOH	3	60	70	73	= 3.31; = 3.72; = 8.30	—
5% H2O2	3	60	80	67	= 2.64; = 3.54	= 3.93; = 7.20

CLP: clopidogrel bisulfate; ATV: atorvastatin.