Statistical Methods for the Investigation of Solvolysis Mechanisms Illustrated by the Chlorides of the Carbomethoxy Protecting Groups NVOC and FMOC

Table 2

Correlations of the specific rates of solvolysis of 1–3, CBZ-Cl, and PNZ-Cl using the extended Grunwald-Winstein equation (2).

Substrate								Mechanism
1	20	1.48 ± 0.13	0.52 ± 0.08	0.04 ± 0.11	0.966	119	2.85	A-E
	26	1.64 ± 0.04	0.54 ± 0.04	0.13 ± 0.06	0.954	116	3.04	A-E
	49	1.66 ± 0.05	0.56 ± 0.03	0.15 ± 0.07	0.980	568	2.96	A-E
CBZ-Cl^h	15	1.95 ± 0.16	0.57 ± 0.05	0.16 ± 0.15	0.966	83	3.42	A-E
	11	0.25 ± 0.05	0.66 ± 0.06	−2.05 ± 0.11	0.976	80	0.38	Ionization-fragmentation
PNZ-Cl^i	19	1.61 ± 0.09	0.46 ± 0.04	0.04 ± 0.22	0.975	157	3.50	A-E

is the number of solvents. ^bWith associated standard error. ^cCorrelation coefficient. -test value. ^eValues taken from [40]. ^fExcluding the data points in aqueous HFIP and aqueous TFE, in regression calculations. Values taken from [40]. ^gCorrelation data from [11]. ^hCorrelation data from [37]. ⁱCorrelation data from [37, 38].