Research Article
Transition Metal Complexes of Naproxen: Synthesis, Characterization, Forced Degradation Studies, and Analytical Method Verification
Table 1
Types of degradation reactions and conditions.
| Degradation reaction | Typical conditions |
| Elevated temperature | Exposed to 105°C heat, up to 3 hours | Acid hydrolysis | Treated with 1 N HCl up to 24 hours | Base hydrolysis | Treated with 1 N NaOH up to 24 hours | Oxidation | Treated with 10% H2O2 solution up to 24 hours | Reduction | Treated with 10% Na bisulfite solution up to 24 hours | Water hydrolysis | Treated with water up to 24 hours |
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