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Journal of Analytical Methods in Chemistry
Volume 2016, Article ID 5976324, 12 pages
http://dx.doi.org/10.1155/2016/5976324
Research Article

Determination of Levetiracetam in Human Plasma by Dispersive Liquid-Liquid Microextraction Followed by Gas Chromatography-Mass Spectrometry

1Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-903 Ribeirão Preto, SP, Brazil
2Department of Exact and Earth Sciences, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, 09972-270 Diadema, SP, Brazil
3Departament of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, 14040-901 Ribeirão Preto, SP, Brazil
4Department of Clinical Analysis, Toxicology and Food Science, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-903 Ribeirão Preto, SP, Brazil

Received 26 June 2016; Accepted 1 September 2016

Academic Editor: Antonio V. Herrera-Herrera

Copyright © 2016 Greyce Kelly Steinhorst Alcantara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. S. Shah, G. Vidyasagar, and H. Barot, “Stability indicating RP-HPLC method for estimation of levetiracetam in pharmaceutical formulation and application to pharmacokinetic study,” Der Pharmacia Sinica, vol. 3, no. 5, pp. 576–589, 2012. View at Google Scholar
  2. E. Oláh, G. Bacsói, J. Fekete, and V. K. Sharma, “Determination of ng/mL levetiracetam using ultra-high-performance liquid chromatography–photodiode absorbance,” Journal of Chromatographic Science, vol. 50, no. 3, pp. 253–258, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. M. D. Krasowski, “Therapeutic drug monitoring of the newer anti-epilepsy medications,” Pharmaceuticals, vol. 3, no. 6, pp. 1909–1935, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. P. N. Patsalos, “Pharmacokinetic profile of levetiracetam: toward ideal characteristics,” Pharmacology & Therapeutics, vol. 85, no. 2, pp. 77–85, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. J. A. French and F. Tonner, “Levetiracetam,” in The Treatment of Epilepsy, S. Shorvon, E. Perucca, and J. Engel, Eds., chapter 44, pp. 559–573, 3rd edition, 2009. View at Google Scholar
  6. H. S. Swaroop, C. Ananya, K. Nithin, C. A. Jayashankar, H. V. S. Babu, and B. N. Srinivas, “Levetiracetam: a review of its use in the treatment of epilepsy,” International Journal of Medicine and Biomedical Research, vol. 2, no. 3, pp. 166–172, 2013. View at Publisher · View at Google Scholar
  7. L. S. Deshpande and R. J. DeLorenzo, “Mechanisms of levetiracetam in the control of status epilepticus and epilepsy,” Frontiers in Neurology, vol. 5, article 11, 5 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. P. N. Patsalos, D. J. Berry, B. F. D. Bourgeois et al., “Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies,” Epilepsia, vol. 49, no. 7, pp. 1239–1276, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Isoherranen, M. Roeder, S. Soback, B. Yagen, V. Schurig, and M. Bialer, “Enantioselective analysis of levetiracetam and its enantiomer R-α- ethyl-2-oxo-pyrrolidine acetamide using gas chromatography and ion trap mass spectrometric detection,” Journal of Chromatography B: Biomedical Sciences and Applications, vol. 745, no. 2, pp. 325–332, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. D. S. Jain, G. S. M. Sanyal, U. Pal, and P. S. Shrivastav, “Determination of levetiracetam in human plasma by liquid chromatography/electrospray tandem mass spectrometry and its application to bioequivalence studies,” Rapid Communications in Mass Spectrometry, vol. 20, no. 17, pp. 2539–2547, 2006. View at Publisher · View at Google Scholar
  11. T. Guo, L. M. Oswald, D. R. Mendu, and S. J. Soldin, “Determination of levetiracetam in human plasma/serum/saliva by liquid chromatography-electrospray tandem mass spectrometry,” Clinica Chimica Acta, vol. 375, no. 1-2, pp. 115–118, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. K. M. Matar, “Quantification of levetiracetam in human plasma by liquid chromatography–tandem mass spectrometry: application to therapeutic drug monitoring,” Journal of Pharmaceutical and Biomedical Analysis, vol. 48, no. 3, pp. 822–828, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. K.-B. Kim, K.-A. Seo, S.-E. Kim, S. K. Bae, D.-H. Kim, and J.-G. Shin, “Simple and accurate quantitative analysis of ten antiepileptic drugs in human plasma by liquid chromatography/tandem mass spectrometry,” Journal of Pharmaceutical and Biomedical Analysis, vol. 56, no. 4, pp. 771–777, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Ratnaraj, H. C. Doheny, and P. N. Patsalos, “A micromethod for the determination of the new antiepileptic drug levetiracetam (ucb LO59) in serum or plasma by high performance liquid chromatography,” Therapeutic Drug Monitoring, vol. 18, no. 2, pp. 154–157, 1996. View at Publisher · View at Google Scholar · View at Scopus
  15. J. M. Juenke, P. I. Brown, F. M. Urry, and G. A. McMillin, “Drug monitoring and toxicology: a procedure for the monitoring of levetiracetam and zonisamide by HPLC-UV,” Journal of Analytical Toxicology, vol. 30, no. 1, pp. 27–30, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. T. A. C. Vermeij and P. M. Edelbroek, “Robust isocratic high performance liquid chromatographic method for simultaneous determination of seven antiepileptic drugs including lamotrigine, oxcarbazepine and zonisamide in serum after solid-phase extraction,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 857, no. 1, pp. 40–46, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Contin, S. Mohamed, F. Albani, R. Riva, and A. Baruzzi, “Simple and validated HPLC-UV analysis of levetiracetam in deproteinized plasma of patients with epilepsy,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 873, no. 1, pp. 129–132, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Ganesan, S. K. Rauthan, S. S. Yadav, Y. Pandey, and P. Tripathi, “Validated liquid chromatographic ultra violet method for the quantization of levetiracetam in human plasma using liquid-liquid extraction,” International Journal of Pharmaceutical Sciences and Research, vol. 1, no. 1, pp. 1–9, 2010. View at Google Scholar
  19. L. Zufía, A. Aldaz, N. Ibáñez, J. Giráldez, and C. Viteri, “LC method for therapeutic drug monitoring of levetiracetam: evaluation of the assay performance and validation of its application in the routine area,” Clinical Biochemistry, vol. 43, no. 4-5, pp. 473–482, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. T. A. C. Vermeij and P. M. Edelbroek, “High-performance liquid chromatographic and megabore gas-liquid chromatographic determination of levetiracetam (ucb L059) in human serum after solid-phase extraction,” Journal of Chromatography B: Biomedical Sciences and Applications, vol. 662, no. 1, pp. 134–139, 1994. View at Publisher · View at Google Scholar · View at Scopus
  21. E. Greiner-Sosanko, S. Giannoutsos, D. R. Lower, M. A. Virji, and M. D. Krasowski, “Drug monitoring: simultaneous analysis of lamotrigine, oxcarbazepine, 10-hydroxycarbazepine, and zonisamide by HPLC-UV and a rapid GC method using a nitrogen-phosphorus detector for levetiracetam,” Journal of Chromatographic Science, vol. 45, no. 9, pp. 616–622, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. V. Pucci, F. Bugamelli, R. Mandrioli, A. Ferranti, E. Kenndler, and M. A. Raggi, “High-performance liquid chromatographic determination of levetiracetam in human plasma: comparison of different sample clean-up procedures,” Biomedical Chromatography, vol. 18, no. 1, pp. 37–44, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Freitas-Lima, F. I. S. Ferreira, C. Bertucci et al., “Stir bar-sorptive extraction, solid phase extraction and liquid-liquid extraction for levetiracetam determination in human plasma: comparing recovery rates,” Brazilian Journal of Pharmaceutical Sciences, vol. 51, no. 2, pp. 393–401, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Heydari and M. Shamsipur, “Rapid enantiomeric separation and quantitation of levetiracetam on α-acid glycoprotein (AGP) chiral stationary phase by high-performance liquid chromatography,” Journal of AOAC International, vol. 98, no. 6, pp. 1529–1534, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Rezaee, Y. Yamini, M. Hojjati, and M. Faraji, “Novel extraction method based on the dispersion of the extraction solvent for extraction of letrozole from biological fluids,” Analytical Methods, vol. 2, no. 9, pp. 1341–1345, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. M. R. Payán, M. Á. B. López, R. F. Torres, M. V. Navarro, and M. C. Mochón, “Electromembrane extraction (EME) and HPLC determination of non-steroidal anti-inflammatory drugs (NSAIDs) in wastewater samples,” Talanta, vol. 85, no. 1, pp. 394–399, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Rezaee, Y. Yamini, and M. Faraji, “Evolution of dispersive liquid-liquid microextraction method,” Journal of Chromatography A, vol. 1217, no. 16, pp. 2342–2357, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Rezaee, Y. Assadi, M.-R. Milani Hosseini, E. Aghaee, F. Ahmadi, and S. Berijani, “Determination of organic compounds in water using dispersive liquid-liquid microextraction,” Journal of Chromatography A, vol. 1116, no. 1-2, pp. 1–9, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. X.-Z. Hu, J.-H. Wu, and Y.-Q. Feng, “Molecular complex-based dispersive liquid–liquid microextraction: analysis of polar compounds in aqueous solution,” Journal of Chromatography A, vol. 1217, no. 45, pp. 7010–7016, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Ma, W. Lu, and L. Chen, “Recent advances in dispersive liquid-liquid microextraction for organic compounds analysis in environmental water: a review,” Current Analytical Chemistry, vol. 8, no. 1, pp. 78–90, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. X.-H. Zang, Q.-H. Wu, M.-Y. Zhang, G.-H. Xi, and Z. Wang, “Developments of dispersive liquid-liquid microextraction technique,” Chinese Journal of Analytical Chemistry, vol. 37, no. 2, pp. 161–168, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. H. A. Mashayekhi, P. Abroomand-Azar, M. Saber-Tehrani, and S. W. Husain, “Rapid determination of carbamazepine in human urine, plasma samples and water using DLLME followed by RP-LC,” Chromatographia, vol. 71, no. 5-6, pp. 517–521, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Xiong, J. Ruan, Y. Cai, and Y. Tang, “Extraction and determination of some psychotropic drugs in urine samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography,” Journal of Pharmaceutical and Biomedical Analysis, vol. 49, no. 2, pp. 572–578, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Chen, C. Xiong, J. Ruan, and Z. Su, “Dispersive liquid-liquid microextraction combined with high-performance liquid chromatography for the determination of clozapine and chlorpromazine in urine,” Journal of Huazhong University of Science and Technology, vol. 31, no. 2, pp. 277–284, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Soltani, A. M. Ramezani, N. Soltani, and A. Jouyban, “Analysis of losartan and carvedilol in urine and plasma samples using a dispersive liquid-liquid microextraction isocratic HPLC-UV method,” Bioanalysis, vol. 4, no. 23, pp. 2805–2821, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. M. B. Melwanki, W.-S. Chen, H.-Y. Bai, T.-Y. Lin, and M.-R. Fuh, “Determination of 7-aminoflunitrazepam in urine by dispersive liquid-liquid microextraction with liquid chromatography-electrospray-tandem mass spectrometry,” Talanta, vol. 78, no. 2, pp. 618–622, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Saraji, M. Khalili Boroujeni, and A. A. Hajialiakbari Bidgoli, “Comparison of dispersive liquid-liquid microextraction and hollow fiber liquid-liquid-liquid microextraction for the determination of fentanyl, alfentanil, and sufentanil in water and biological fluids by high-performance liquid chromatography,” Analytical and Bioanalytical Chemistry, vol. 400, no. 7, pp. 2149–2158, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. A. B. Tabrizi and N. S. Tutunchi, “Analysis of piroxicam in pharmaceutical formulation and human urine by dispersive liquid–liquid microextraction combined with spectrophotometry,” Advanced Pharmaceutical Bulletin, vol. 3, no. 1, pp. 37–44, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. E. Ranjbari, A.-A. Golbabanezhad-Azizi, and M. R. Hadjmohammadi, “Preconcentration of trace amounts of methadone in human urine, plasma, saliva and sweat samples using dispersive liquid-liquid microextraction followed by high performance liquid chromatography,” Talanta, vol. 94, pp. 116–122, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. H. Ghambari and M. Hadjmohammadi, “Low-density solvent-based dispersive liquid-liquid microextraction followed by high performance liquid chromatography for determination of warfarin in human plasma,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 899, pp. 66–71, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Shamsipur Mojtaba and N. Fattahi, “Extraction and determination of opium alkaloids in urine samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 879, no. 28, pp. 2978–2983, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Jouyban, M. H. Sorouraddin, M. A. Farajzadeh, M. H. Somi, and R. Fazeli-Bakhtiyari, “Determination of five antiarrhythmic drugs in human plasma by dispersive liquid-liquid microextraction and high-performance liquid chromatography,” Talanta, vol. 134, pp. 681–689, 2015. View at Publisher · View at Google Scholar · View at Scopus
  43. P. Fernández, M. Regenjo, A. M. Bermejo, A. M. Fernández, R. A. Lorenzo, and A. M. Carro, “Analysis of drugs of abuse in human plasma by dispersive liquid-liquid microextraction and high-performance liquid chromatography,” Journal of Applied Toxicology, vol. 35, no. 4, pp. 418–425, 2015. View at Publisher · View at Google Scholar · View at Scopus
  44. R. Heydari, M. Rashidipour, and N. Naleini, “Determination of efavirenz in plasma by dispersive liquid-liquid microextraction coupled to high-performance liquid chromatography,” Current Analytical Chemistry, vol. 10, no. 2, pp. 280–287, 2014. View at Publisher · View at Google Scholar · View at Scopus
  45. European Agency for the Evaluation of Medical Products—EMA, Guideline on Bioanalytical Method Validation, 2011
  46. A. M. Almeida, M. M. Castel-Branco, and A. C. Falcão, “Linear regression for calibration lines revisited: weighting schemes for bioanalytical methods,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 774, no. 2, pp. 215–222, 2002. View at Publisher · View at Google Scholar · View at Scopus
  47. A. M. Carro, S. Fernández, I. Racamonde, D. García-Rodríguez, P. González, and R. A. Lorenzo, “Dispersive liquid-liquid microextraction coupled with programmed temperature vaporization-large volume injection-gas chromatography-tandem mass spectrometry for multiclass pesticides in water,” Journal of Chromatography A, vol. 1253, pp. 134–143, 2012. View at Publisher · View at Google Scholar · View at Scopus
  48. M. López-Nogueroles, A. Chisvert, and A. Salvador, “Determination of atranol and chloroatranol in perfumes using simultaneous derivatization and dispersive liquid–liquid microextraction followed by gas chromatography–mass spectrometry,” Analytica Chimica Acta, vol. 826, no. 1, pp. 28–34, 2014. View at Publisher · View at Google Scholar · View at Scopus
  49. M. L. Martins, E. G. Primel, and S. S. Caldas, “Microextração Líquido-Líquido Dispersiva (DLLME): fundamentos e aplicações,” Scientia Chromatographica, vol. 4, no. 1, pp. 35–51, 2012. View at Google Scholar
  50. M. B. Melwanki and M.-R. Fuh, “Dispersive liquid-liquid microextraction combined with semi-automated in-syringe back extraction as a new approach for the sample preparation of ionizable organic compounds prior to liquid chromatography,” Journal of Chromatography A, vol. 1198-1199, no. 1-2, pp. 1–6, 2008. View at Publisher · View at Google Scholar · View at Scopus
  51. Analytical Methods Committee Technical Briefs, “The Royal Society of chemistry 3,” 2000
  52. J. J. B. Nevado, C. G. Cabanillas, M. J. V. Llerena, and V. R. Robledo, “Enantiomeric determination, validation and robustness studies of racemic citalopram in pharmaceutical formulations by capillary electrophoresis,” Journal of Chromatography A, vol. 1072, no. 2, pp. 249–257, 2005. View at Publisher · View at Google Scholar · View at Scopus
  53. G. M. Hadad, R. A. A. Salam, and E. A. A. Hameed, “Quantitative determination of levetiracetam in human urine using HPLC-UV and its identification by LC-ESI-MS,” Journal of Liquid Chromatography and Related Technologies, vol. 36, no. 18, pp. 2568–2579, 2013. View at Publisher · View at Google Scholar · View at Scopus