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Journal of Analytical Methods in Chemistry
Volume 2016, Article ID 7862152, 6 pages
http://dx.doi.org/10.1155/2016/7862152
Research Article

Magnetic Solid-Phase Extraction Based on β-Cyclodextrins/Acrylic Acid Modified Magnetic Gelatin for Determination of Moxidectin in Milk Samples

Hubei Entry-Exit Inspection and Quarantine Bureau of PRC, Wuhan 430022, China

Received 22 December 2015; Revised 7 March 2016; Accepted 3 May 2016

Academic Editor: Miren Lopez de Alda

Copyright © 2016 Yinzhu Shang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

β-Cyclodextrins/acrylic acid modified magnetic gelatin was prepared and then employed as the magnetic solid-phase extraction (MSPE) sorbent for extraction of moxidectin in milk samples. Due to the rigidity of hydrophobic cavity of β-cyclodextrins and carboxyl groups of acrylic acid, magnetic composites are prepared to form a complex with target molecules through various kinds of chemical reactions and then showed excellent extraction performance. This method exhibits the advantages of simplicity of implementation, short extraction time (5 min), low solvent consumption, and high extraction efficiency. A rapid, simple, and effective method for the analysis of moxidectin in milk samples was established by MSPE coupled with liquid chromatography-fluorescence detection. The limit of detection was 0.1 ng·mL−1 and the recoveries from milk samples were in the range of 93.8%–112.5%. The relative standard deviation was not higher than 6.4%. In conclusion, magnetic solid-phase extraction is a simple and robust preconcentration technique that can be coupled to other analytical methods for the quantitative determination of target molecules in complex samples.