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Journal of Analytical Methods in Chemistry
Volume 2017, Article ID 1073607, 13 pages
Research Article

Metabolite Profiling, Pharmacokinetics, and In Vitro Glucuronidation of Icaritin in Rats by Ultra-Performance Liquid Chromatography Coupled with Mass Spectrometry

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China

Correspondence should be addressed to Shuzhang Du; moc.361@119gnahzuhsud and Xiaojian Zhang; moc.361@bxy_naijoaixgnahz

Received 5 April 2017; Accepted 23 May 2017; Published 10 July 2017

Academic Editor: Filomena Conforti

Copyright © 2017 Beibei Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table S1: Leaner range and LLOQ test of icaritin in rat plasma. Table S2: Matrix effect and recovery test of icaritin in rat plasma (n = 6). Table S3: Intra- and inter-day precision and accuracy test of icaritin in rat plasma. Table S4: Stability test of icaritin in rat plasma under different condition (n = 3). Figure S1: (+) ESI-MS and MS/MS spectra of M0~M30. Figure S2: EICs of M0~M30 in rat intestine samples. Figure S3: Specificity test of icaritin in rat plasma.

  1. Supplementary Material