UPLC-Tandem Mass Spectrometry Method for Simultaneous Determination of Fluoxetine, Risperidone, and Its Active Metabolite 9-Hydroxyrisperidone in Plasma: Application to Pharmacokinetics Study in Rats

Table 1

Mass optimization parameters for FLX, RIS, 9-OH-RIS, and OLA.

Parameters	FLX	RIS	9-OH-RIS	OLA
	Source-dependent parameters
SRM transition
Parent	309.79	411.3	427.07	313.0
Daughter	44.18	191.12	206.97	256.03
Collision energy (eV)	15	45	45	40
Cone voltages	20	30	25	20
	Compound-dependent parameters
Collision gas	Argon with a flow rate of 0.1 ML/min
Desolvating gas	Nitrogen with flow rate of 600 L/h
Desolvating temperature	350
Source temperature	150
Capillary voltage	4 kV